The Cost-effectiveness Analysis of Drug Therapy Versus Surgery for Symptomatic Adenoid Hypertrophy by a Markov Model

Overview

Journal Qual Life Res

Specialties Pharmacology
Rehabilitation Medicine

Date 2019 Nov 30

PMID 31782019

Citations 3

Authors

Han Xiao

Jinqiang Huang

Weifeng Liu

Zihao Dai

Sui Peng

Zhenwei Peng

Ruiming Liang

Renqiang Ma

Yihui Wen

Jian Li

Weiping Wen

Affiliations

Soon will be listed here.

Abstract

Purpose: Adenoid hypertrophy (AH) is common among young children. Adenoid-based surgery and drug therapy could be applied for symptomatic AH patients, yet the treatment decision is difficult to make due to the diverse cost and efficacy between these two treatments.

Methods: A Markov simulation model was designed to estimate the cost-effectiveness (CE) of the adenoid-based surgery and the drug therapy for symptomatic AH patients. Transition probabilities, costs and utilities were extracted from early researches and expert opinions. Simulations using two set of parameter inputs for China and the USA were performed. Primary outcome was cost per QALY gained over a 6-year period. Deterministic and probabilistic sensitivity analyses were also conducted.

Results: The utility for the surgery group and the drug group were 4.10 quality-adjusted life years (QALYs) and 3.58 QALYs, respectively. The cost of the surgery group was more than that of the drug group using model parameters specific to China ($1069.0 vs. $753.7) but was less for the USA ($1994.4 vs. $3977.7). Surgery was dominant over drug therapy when US specific parameters were used. Surgery group had an ICER of $604.0 per QALY when parameters specific to China was used.

Conclusion: Surgery is cost-effective in the simulations for both China and the USA at WTP thresholds of $9633.1 and $62,517.5, respectively.

Citing Articles

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