Emerging Role of Ferroptosis in Acute Kidney Injury

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2019 Nov 30

PMID 31781351

Citations 86

Authors

Zhaoxin Hu

Hao Zhang

Shi-Kun Yang

Xueqin Wu

Dong He

Ke Cao

Wei Zhang

Affiliations

Soon will be listed here.

Abstract

Acute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic cell death characterized by membrane lipid peroxide accumulation and polyunsaturated fatty acid consumption, and it plays essential roles in many diseases, including cancers and neurologic diseases. Recent studies have revealed an emerging role of ferroptosis in the pathophysiological processes of AKI. Here, in the present review, we summarized the most recent discoveries on the role of ferroptosis in the pathogenesis of AKI as well as its therapeutic potential in AKI.

Citing Articles

Deciphering ferroptosis in critical care: mechanisms, consequences, and therapeutic opportunities.

Tan R, Ge C, Yan Y, Guo H, Han X, Zhu Q Front Immunol. 2024; 15:1511015.

PMID: 39737174 PMC: 11682965. DOI: 10.3389/fimmu.2024.1511015.

Dexmedetomidine inhibits ferroptosis and attenuates sepsis-induced acute kidney injury via activating the Nrf2/SLC7A11/FSP1/CoQ10 pathway.

Huang J, Zhao Y, Luo X, Luo Y, Ji J, Li J Redox Rep. 2024; 29(1):2430929.

PMID: 39581576 PMC: 11587839. DOI: 10.1080/13510002.2024.2430929.

The significance of ferroptosis in renal diseases and its therapeutic potential.

Jiang M, Wu S, Xie K, Zhou G, Zhou W, Bao P Heliyon. 2024; 10(16):e35882.

PMID: 39220983 PMC: 11363859. DOI: 10.1016/j.heliyon.2024.e35882.

Comprehensive analysis of cuproptosis-related genes in immune infiltration and development of a novel diagnostic model for acute kidney injury.

Li Y, Ding Y Ren Fail. 2024; 46(1):2325035.

PMID: 38538321 PMC: 10977005. DOI: 10.1080/0886022X.2024.2325035.

Gong Y, Zhang C, Li H, Yu X, Li Y, Liu Z Curr Issues Mol Biol. 2024; 46(3):1886-1903.

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References

Zager R, Burkhart K . Myoglobin toxicity in proximal human kidney cells: roles of Fe, Ca2+, H2O2, and terminal mitochondrial electron transport. Kidney Int. 1997; 51(3):728-38. DOI: 10.1038/ki.1997.104. View

KNOCHEL J . Mechanisms of rhabdomyolysis. Curr Opin Rheumatol. 1993; 5(6):725-31. DOI: 10.1097/00002281-199305060-00006. View

Linkermann A, Skouta R, Himmerkus N, Mulay S, Dewitz C, De Zen F . Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A. 2014; 111(47):16836-41. PMC: 4250130. DOI: 10.1073/pnas.1415518111. View

Paller M . Hemoglobin- and myoglobin-induced acute renal failure in rats: role of iron in nephrotoxicity. Am J Physiol. 1988; 255(3 Pt 2):F539-44. DOI: 10.1152/ajprenal.1988.255.3.F539. View

Thiele R, Isbell J, Rosner M . AKI associated with cardiac surgery. Clin J Am Soc Nephrol. 2014; 10(3):500-14. PMC: 4348689. DOI: 10.2215/CJN.07830814. View

Boutaud O, Roberts 2nd L . Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure. Free Radic Biol Med. 2010; 51(5):1062-7. PMC: 3116013. DOI: 10.1016/j.freeradbiomed.2010.10.704. View

Conrad M, Friedmann Angeli J, Vandenabeele P, Stockwell B . Regulated necrosis: disease relevance and therapeutic opportunities. Nat Rev Drug Discov. 2016; 15(5):348-66. PMC: 6531857. DOI: 10.1038/nrd.2015.6. View

Linkermann A, Chen G, Dong G, Kunzendorf U, Krautwald S, Dong Z . Regulated cell death in AKI. J Am Soc Nephrol. 2014; 25(12):2689-701. PMC: 4243360. DOI: 10.1681/ASN.2014030262. View

Neitemeier S, Jelinek A, Laino V, Hoffmann L, Eisenbach I, Eying R . BID links ferroptosis to mitochondrial cell death pathways. Redox Biol. 2017; 12:558-570. PMC: 5382034. DOI: 10.1016/j.redox.2017.03.007. View

10.

Brade W, Herken H, Merker H . Regeneration of renal tubular cells after lesion by temporary ischaemia, folic acid, and 2,4,5-triamino 6-styrylpyrimidine. Naunyn Schmiedebergs Arch Pharmakol. 1970; 266(1):95-100. DOI: 10.1007/BF00997785. View

11.

Sogabe K, Roeser N, Venkatachalam M, Weinberg J . Differential cytoprotection by glycine against oxidant damage to proximal tubule cells. Kidney Int. 1996; 50(3):845-54. DOI: 10.1038/ki.1996.384. View

12.

Fink M, Henry M, Tange J . Experimental folic acid nephropathy. Pathology. 1987; 19(2):143-9. DOI: 10.3109/00313028709077125. View

13.

Malek M, Nematbakhsh M . Renal ischemia/reperfusion injury; from pathophysiology to treatment. J Renal Inj Prev. 2015; 4(2):20-7. PMC: 4459724. DOI: 10.12861/jrip.2015.06. View

14.

Valko M, Morris H, Cronin M . Metals, toxicity and oxidative stress. Curr Med Chem. 2005; 12(10):1161-208. DOI: 10.2174/0929867053764635. View

15.

Guerrero-Hue M, Garcia-Caballero C, Palomino-Antolin A, Rubio-Navarro A, Vazquez-Carballo C, Herencia C . Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. FASEB J. 2019; 33(8):8961-8975. DOI: 10.1096/fj.201900077R. View

16.

Hirschhorn T, Stockwell B . The development of the concept of ferroptosis. Free Radic Biol Med. 2018; 133:130-143. PMC: 6368883. DOI: 10.1016/j.freeradbiomed.2018.09.043. View

17.

Skouta R, Dixon S, Wang J, Dunn D, Orman M, Shimada K . Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc. 2014; 136(12):4551-6. PMC: 3985476. DOI: 10.1021/ja411006a. View

18.

Cramer S, Saha A, Liu J, Tadi S, Tiziani S, Yan W . Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth. Nat Med. 2016; 23(1):120-127. PMC: 5218918. DOI: 10.1038/nm.4232. View

19.

Wu D, Chen L . Ferroptosis: a novel cell death form will be a promising therapy target for diseases. Acta Biochim Biophys Sin (Shanghai). 2015; 47(10):857-9. DOI: 10.1093/abbs/gmv086. View

20.

Agarwal A, Nick H . Renal response to tissue injury: lessons from heme oxygenase-1 GeneAblation and expression. J Am Soc Nephrol. 2000; 11(5):965-973. DOI: 10.1681/ASN.V115965. View