Gentle Manual Acupuncture Could Better Regulate Gastric Motility and Vagal Afferent Nerve Discharge of Rats with Gastric Hypomotility

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2019 Nov 30

PMID 31781283

Citations 3

Authors

YangYang Liu

Yang Bai

Yue Pan

Zhifang Xu

Yuxin Fang

Shenjun Wang

Yuanhao Du

Yi Guo

Affiliations

Soon will be listed here.

Abstract

The variation of stimulus intensity of manual acupuncture (MA) may produce diverse acupuncture effects. However, the intensity-effect relationship and the underlying mechanism of MA are still elusive. In this study, the effects of MA regulation of gastric motility were investigated after lifting-thrusting MA treatment with four different frequencies (1 Hz, 2 Hz, 3 Hz, and 4 Hz) at ST36. The experiments were conducted on rats with gastric hypomotility caused by atropine. The results showed that the gastric motility amplitude decreased after atropine injection, while the treatment of four types of MA affected the gastric motility amplitude in varying degrees. Specifically, 2 Hz MA exhibited the most effective results, while 4 Hz MA had the least effect; the effects of 1 Hz MA and 3 Hz MA were between the effects induced with 2 Hz and 4 Hz. Furthermore, the response of gastric vagal afferent nerve discharge and gastric motility was examined after MA treatment with frequencies of 2 Hz and 4 Hz, respectively, on ST36 in order to elucidate the mechanism of MA regulation of gastric motility. The results showed that 2 Hz MA was able to increase the amplitude of gastric motility and discharge frequency of gastric vagal afferent nerves, while 4 Hz MA exhibited seldom effects. These findings suggest that gentle MA (2 Hz) has more stimulating effects than strong stimulation with MA (4 Hz) on gastric hypomotility. In addition, gastric motility regulated by MA was associated with vagal afferent nerve activation.

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References

Gao L, Guo Y, Sha T, Liu Y, Tang J, Yuan F . Differential effects of variable frequencies of manual acupuncture at ST36 in rats with atropine-induced inhibition of gastric motility. Acupunct Med. 2015; 34(1):33-9. DOI: 10.1136/acupmed-2015-010756. View

Fang J, Du J, Shao X, Fang J, Liu Z . Effect of Electroacupuncture on the NTS is modulated primarily by acupuncture point selection and stimulation frequency in normal rats. BMC Complement Altern Med. 2017; 17(1):182. PMC: 5374564. DOI: 10.1186/s12906-017-1690-7. View

Yin J, Chen J . Gastrointestinal motility disorders and acupuncture. Auton Neurosci. 2010; 157(1-2):31-7. PMC: 2906692. DOI: 10.1016/j.autneu.2010.03.007. View

Li G, Huang C, Zhang X, Xie H, Cheng H, Tang Y . The short-term effects of acupuncture on patients with diabetic gastroparesis: a randomised crossover study. Acupunct Med. 2015; 33(3):204-9. DOI: 10.1136/acupmed-2014-010670. View

Zhang Z, Wang C, Li Q, Zhang M, Zhao H, Dong L . Electroacupuncture at ST36 accelerates the recovery of gastrointestinal motility after colorectal surgery: a randomised controlled trial. Acupunct Med. 2014; 32(3):223-6. DOI: 10.1136/acupmed-2013-010490. View

Yang M, Li X, Liu S, Li Z, Xue M, Gao D . Meta-analysis of acupuncture for relieving non-organic dyspeptic symptoms suggestive of diabetic gastroparesis. BMC Complement Altern Med. 2013; 13:311. PMC: 4226258. DOI: 10.1186/1472-6882-13-311. View

Wang J, Liu X, Qin M, Chen L, Qiu J, Duan L . Electro-acupuncture of Tsusanli and Shangchuhsu regulates gastric activity possibly through mediation of the vagus-solotary complex. Hepatogastroenterology. 2007; 54(78):1862-7. View

Travagli R, Anselmi L . Vagal neurocircuitry and its influence on gastric motility. Nat Rev Gastroenterol Hepatol. 2016; 13(7):389-401. PMC: 5605144. DOI: 10.1038/nrgastro.2016.76. View

Liu J, Huang H, Xu X, Chen J . Effects and possible mechanisms of acupuncture at ST36 on upper and lower abdominal symptoms induced by rectal distension in healthy volunteers. Am J Physiol Regul Integr Comp Physiol. 2012; 303(2):R209-17. PMC: 3404632. DOI: 10.1152/ajpregu.00301.2010. View

10.

Sengupta J, Petersen J, Peles S, Shaker R . Response properties of antral mechanosensitive afferent fibers and effects of ionotropic glutamate receptor antagonists. Neuroscience. 2004; 125(3):711-23. DOI: 10.1016/j.neuroscience.2004.02.018. View

11.

Sato A, Sato Y, Suzuki A, Uchida S . Neural mechanisms of the reflex inhibition and excitation of gastric motility elicited by acupuncture-like stimulation in anesthetized rats. Neurosci Res. 1993; 18(1):53-62. DOI: 10.1016/0168-0102(93)90105-y. View

12.

Xu Y, Hong S, Zhao X, Wang S, Xu Z, Ding S . Acupuncture Alleviates Rheumatoid Arthritis by Immune-Network Modulation. Am J Chin Med. 2018; 46(5):997-1019. DOI: 10.1142/S0192415X18500520. View

13.

Wang L, Jing M, Zhi J, Lu J, Wang C, Liu Q . [Effects of reinforcing and reducing methods by twirling and rotating the needle on contents of CGRP and NO in rats with stress-induced hypertension]. Zhongguo Zhen Jiu. 2011; 31(4):337-41. View

14.

Bu F, Wei F, Dai X, Tan Q, Cheng B . [Progress on the Relationship Between the Regulation of Gastrointestinal System Function by Acupuncture and Central Nuclei]. Zhen Ci Yan Jiu. 2017; 42(4):363-6. View

15.

Gao X, Yuan J, Li H, Ren S . Clinical research on acupuncture and moxibustion treatment of chronic atrophic gastritis. J Tradit Chin Med. 2007; 27(2):87-91. View

16.

Anders E, Findeisen A, Lode H, Usichenko T . Acupuncture for treatment of acute vomiting in children with gastroenteritis and pneumonia. Klin Padiatr. 2011; 224(2):72-5. DOI: 10.1055/s-0031-1283144. View

17.

Zhang W, Li B, Sun J, Wang Z, Zhang N, Shi F . [Therapeutic effects of the integrated acupuncture and Chinese herbal medicine on reflux esophagitis]. Zhongguo Zhen Jiu. 2017; 37(7):729-733. DOI: 10.13703/j.0255-2930.2017.07.012. View

18.

Han J, Ho Y . Global trends and performances of acupuncture research. Neurosci Biobehav Rev. 2010; 35(3):680-7. DOI: 10.1016/j.neubiorev.2010.08.006. View

19.

Ho R, Chung V, Wong C, Wu J, Wong S, Wu I . Acupuncture and related therapies used as add-on or alternative to prokinetics for functional dyspepsia: overview of systematic reviews and network meta-analysis. Sci Rep. 2017; 7(1):10320. PMC: 5583250. DOI: 10.1038/s41598-017-09856-0. View

20.

Yan C, Peng Y, Lin Y, Yi S, Chen P, Hou Y . [Effect of manual acupuncture stimulation of "Zusanli" (ST 36) on gastric motility, and SP and motilin activities in gastric antrum and nucleus raphe magnus in gastric hyperactivity and hypoactivity rats]. Zhen Ci Yan Jiu. 2013; 38(5):345-51. View