Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2019 Nov 30

PMID 31781041

Citations 16

Authors

Katia Mariniello

Gerard Ruiz-Babot

Emily C McGaugh

James G Nicholson

Angelica Gualtieri

Carles Gaston-Massuet

Maria Cristina Nostro

Leonardo Guasti

Affiliations

Soon will be listed here.

Abstract

The endocrine system coordinates a wide array of body functions mainly through secretion of hormones and their actions on target tissues. Over the last decades, a collective effort between developmental biologists, geneticists, and stem cell biologists has generated a wealth of knowledge related to the contribution of stem/progenitor cells to both organogenesis and self-renewal of endocrine organs. This review provides an up-to-date and comprehensive overview of the role of tissue stem cells in the development and self-renewal of endocrine organs. Pathways governing crucial steps in both development and stemness maintenance, and that are known to be frequently altered in a wide array of endocrine disorders, including cancer, are also described. Crucially, this plethora of information is being channeled into the development of potential new cell-based treatment modalities for endocrine-related illnesses, some of which have made it through clinical trials.

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