Neuroimaging in Vascular Parkinsonism

Overview

Journal Curr Neurol Neurosci Rep

Specialty Neurology

Date 2019 Nov 28

PMID 31773419

Citations 8

Authors

Karen K Y Ma

Shi Lin

Vincent C T Mok

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Being a disease with heterogeneous presentations and unclear consensus on its diagnostic criteria, it is difficult to differentiate vascular parkinsonism (VaP) from other neurodegenerative parkinsonism variants. Ongoing research on structural and functional neuroimaging targeting dopaminergic pathway provides us more insight into the pathophysiology of VaP to improve diagnostic accuracy. The aim of this article is to review how the emerging imaging modalities help the diagnostic process and treatment decision in VaP.

Recent Findings: Dopamine transporter imaging is a promising tool in differentiating presynaptic parkinsonism and VaP. It also predicts the levodopa responders in VaP. Advanced MRI techniques including volumetry, diffusion tensor imaging and sequences visualising substantia nigra are under development, and they are complementary to each other in detecting structural and functional changes in VaP, which is crucial to ensure the quality of future therapeutic trials for VaP. Dopamine transporter imaging is recommended to patients with suspected VaP. Multimodal MRI in VaP would be an important area to be investigated in the near future.

Citing Articles

Vascular parkinsonism showing dopamine transporter scan findings mimicking those of Parkinson's disease.

Sakuramoto H, Fujita H, Ogaki K, Suzuki K eNeurologicalSci. 2024; 37:100528.

PMID: 39346749 PMC: 11437957. DOI: 10.1016/j.ensci.2024.100528.

Atypical Parkinsonian Syndromes: Structural, Functional, and Molecular Imaging Features.

Keir G, Roytman M, Mashriqi F, Shahsavarani S, Franceschi A AJNR Am J Neuroradiol. 2024; 45(12):1865-1877.

PMID: 39209485 PMC: 11630880. DOI: 10.3174/ajnr.A8313.

Preservation of Dopamine Transporters in a Patient With Micrographia Due to Cerebral Infarction: A Case Report.

Arakaki Y, Yoshimoto T, Ishiyama H, Tanaka T, Hattori Y, Ihara M J Mov Disord. 2023; 16(2):221-223.

PMID: 37258282 PMC: 10236017. DOI: 10.14802/jmd.23033.

Parkinsonism Is Associated with Altered SMA-Basal Ganglia Structural and Functional Connectivity in Frontotemporal Degeneration.

Piervincenzi C, Suppa A, Petsas N, Fabbrini A, Trebbastoni A, Asci F Biomedicines. 2023; 11(2).

PMID: 36831058 PMC: 9953061. DOI: 10.3390/biomedicines11020522.

The correlation between enlarged perivascular spaces and cognitive impairment in Parkinson's disease and vascular parkinsonism.

Tu Y, Zhuo W, Peng J, Huang R, Li B, Liu Y BMC Neurol. 2022; 22(1):282.

PMID: 35906550 PMC: 9336003. DOI: 10.1186/s12883-022-02819-7.

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