Upper Limb Motor Improvement in Chronic Stroke After Combining Botulinum Toxin A Injection and Multi-joints Robot-assisted Therapy: a Case Report

Overview

Journal Oxf Med Case Reports

Specialty General Medicine

Date 2019 Nov 28

PMID 31772737

Citations 3

Authors

Alex Martino Cinnera

Alessandra Pucello

Alessandro Lupo

Francesca Gimigliano

Elisa Mammucari

Dario Lo Cicero

Marco Iosa

Stefano Paolucci

Giovanni Morone

Affiliations

Soon will be listed here.

Abstract

Spasticity is one of the major complications after stroke. Botulinum toxin type A (BoNT-A) injection is commonly used to manage focal spasticity. However, it is uncertain whether BoNT-A can improve activities of daily living function of paretic arm. The recovery of functions of the affected arm is also the aim of robotic upper limb (UL) therapy. The motorized exoskeleton assists the patient in a large 3D work environment by promoting movement for the UL (shoulder, elbow, wrist, hand). The combination of the BoNT-A injection and the robotic therapy might enhance functional recovery after stroke. We reported the case of a chronic stroke patient in which the injection of BoNT-A was combined with multi-joint exoskeleton training. The patient showed improvement in the motor control of the UL, supporting the feasibility of this approach.

Citing Articles

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Active, Actuated, and Assistive: a Scoping Review of Exoskeletons for the Hands and Wrists.

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Feasibility of Adjunct Therapy with a Robotic Hand Orthosis after Botulinum Toxin Injections in Persons with Spasticity: A Pilot Study.

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Botulinum Toxin Type A Possibly Affects Ca3.2 Calcium Channel Subunit in Rats with Spinal Cord Injury-Induced Muscle Spasticity.

Ma K, Zhu D, Zhang C, Lv L Drug Des Devel Ther. 2020; 14:3029-3041.

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