Occurrence of Major Anti-retinal Autoantibodies Associated with Paraneoplastic Autoimmune Retinopathy

Overview

Journal Clin Immunol

Specialty Allergy & Immunology

Date 2019 Nov 27

PMID 31770612

Citations 25

Authors

Grazyna Adamus

Rachel Champaigne

Sufang Yang

Affiliations

Soon will be listed here.

Abstract

Autoantibodies (AAbs) against retinal antigens can be found in patients with cancer and unexplained vision loss unrelated to the cancer metastasis. Cancer-associated retinopathy (CAR) is a rare paraneoplastic visual syndrome mediated by AAbs. Our goal was to determine whether CAR patients with different malignancies have a specific AAb or repertoire of AAbs that could serve as biomarkers for retinal disease. We found AAbs against 12 confirmed retinal antigens, with α-enolase being the most frequently recognized. The significant finding of the study was a high incidence of anti-aldolase AAbs in colon-CAR, anti-CAII in prostate-CAR, and anti-arrestin in skin melanoma patients thus these AAbs could serve as biomarkers in the context of clinical presentation and could support the diagnosis of CAR. However, a lack of AAb restriction to any one antigenic protein or to one retinal cellular location makes screening for a CAR biomarker challenging.

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