Epigenetics and the Dynamics of Chromatin During Adenovirus Infections

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 2019 Nov 27

PMID 31769503

Citations 17

Authors

Kelsey L Lynch

Linda R Gooding

Charlie Garnett-Benson

David A Ornelles

Daphne C Avgousti

Affiliations

Soon will be listed here.

Abstract

The DNA genome of eukaryotic cells is compacted by histone proteins within the nucleus to form chromatin. Nuclear-replicating viruses such as adenovirus have evolved mechanisms of chromatin manipulation to promote infection and subvert host defenses. Epigenetic factors may also regulate persistent adenovirus infection and reactivation in lymphoid tissues. In this review, we discuss the viral proteins E1A and protein VII that interact with and alter host chromatin, as well as E4orf3, which separates host chromatin from sites of viral replication. We also highlight recent advances in chromatin technologies that offer new insights into virus-directed chromatin manipulation. Beyond the role of chromatin in the viral replication cycle, we discuss the nature of persistent viral genomes in lymphoid tissue and cell lines, and the potential contribution of epigenetic signals in maintaining adenovirus in a quiescent state. By understanding the mechanisms through which adenovirus manipulates host chromatin, we will understand new aspects of this ubiquitous virus and shed light on previously unknown aspects of chromatin biology.

Citing Articles

Viral imitation is the sincerest form of epigenetic flattery.

Smith J, Arellano A, Avgousti D Mol Biol Cell. 2024; 35(10):pe3.

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Adenovirus small E1A directs activation of Alu transcription at YAP/TEAD- and AP-1-bound enhancers through interactions with the EP400 chromatin remodeler.

Cantarella S, Vezzoli M, Carnevali D, Morselli M, Zemke N, Montanini B Nucleic Acids Res. 2024; 52(16):9481-9500.

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Pulmonary Pathogen-Induced Epigenetic Modifications.

Wrede D, Bordak M, Abraham Y, Mehedi M Epigenomes. 2023; 7(3).

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Hepatitis C virus fitness can influence the extent of infection-mediated epigenetic modifications in the host cells.

Garcia-Crespo C, Francisco-Recuero I, Gallego I, Camblor-Murube M, Soria M, Lopez-Lopez A Front Cell Infect Microbiol. 2023; 13:1057082.

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Chromatin accessibility: methods, mechanisms, and biological insights.

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