Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2019 Nov 27

PMID 31769428

Citations 10

Authors

Lenche Kostadinova

Carey L Shive

Donald D Anthony

Affiliations

Soon will be listed here.

Abstract

Circulating autotaxin (ATX) is elevated in persons with liver disease, particularly in the setting of chronic hepatitis C virus (HCV) and HCV/HIV infection. It is thought that plasma ATX levels are, in part, attributable to impaired liver clearance that is secondary to fibrotic liver disease. In a discovery data set, we identified plasma ATX to be associated with parameters of systemic immune activation during chronic HCV and HCV/HIV infection. We and others have observed a partial normalization of ATX levels within months of starting interferon-free direct-acting antiviral (DAA) HCV therapy, consistent with a non-fibrotic liver disease contribution to elevated ATX levels, or HCV-mediated hepatocyte activation. Relationships between ATX, lysophosphatidic acid (LPA) and parameters of systemic immune activation will be discussed in the context of HCV infection, age, immune health, liver health, and hepatocellular carcinoma (HCC).

Citing Articles

Serum Autotaxin Levels Predict Liver-Related Events in Patients With Primary Biliary Cholangitis: A Long-Term Multicenter Observational Study.

Iwadare T, Kimura T, Yamashita Y, Okumura T, Wakabayashi S, Kobayashi H Clin Transl Gastroenterol. 2024; 15(12):e00779.

PMID: 39466702 PMC: 11671064. DOI: 10.14309/ctg.0000000000000779.

Serum autotaxin is a prognostic indicator of liver-related events in patients with non-alcoholic fatty liver disease.

Iwadare T, Kimura T, Okumura T, Wakabayashi S, Nakajima T, Kondo S Commun Med (Lond). 2024; 4(1):73.

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Rising Lysophosphatidylcholine Levels Post-Hepatitis C Clearance.

Peschel G, Krautbauer S, Weigand K, Grimm J, Horing M, Liebisch G Int J Mol Sci. 2024; 25(2).

PMID: 38256273 PMC: 10816147. DOI: 10.3390/ijms25021198.

Regulation of CD8 T-cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid.

Torres R, Turner J, DAntonio M, Pelanda R, Kremer K Immunol Rev. 2023; 317(1):203-222.

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gene and autotaxin-lysophosphatidic acid axis in gastrointestinal cancers.

Wang S, Chen J, Guo X World J Gastrointest Oncol. 2022; 14(8):1388-1405.

PMID: 36160748 PMC: 9412925. DOI: 10.4251/wjgo.v14.i8.1388.

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