Ferroptosis and Kidney Diseases

Overview

Journal Int Urol Nephrol

Publisher Springer

Specialty Nephrology

Date 2019 Nov 27

PMID 31768804

Citations 33

Authors

Shumei Tang

Xiangcheng Xiao

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is a form of iron-dependent, non-apoptotic regulated cell death, which is characterized by the accumulation of lipid hydroperoxides to lethal levels. Ferroptosis recently has been shown to have implications in diverse kidney diseases, such as acute kidney injury, polycystic kidney disease and renal cell carcinoma. This review summarizes current research on ferroptosis, its underlying mechanisms and its role in the progression of different kidney diseases to provide more information regarding treatment and prevention of these destructive diseases.

Citing Articles

Unveiling ferroptosis: a new frontier in skin disease research.

Wang K, Lin Y, Zhou D, Li P, Zhao X, Han Z Front Immunol. 2024; 15:1485523.

PMID: 39430757 PMC: 11486644. DOI: 10.3389/fimmu.2024.1485523.

The significance of ferroptosis in renal diseases and its therapeutic potential.

Jiang M, Wu S, Xie K, Zhou G, Zhou W, Bao P Heliyon. 2024; 10(16):e35882.

PMID: 39220983 PMC: 11363859. DOI: 10.1016/j.heliyon.2024.e35882.

FGF21 relieves calcium oxalate-induced cell injury, apoptosis, oxidative damage and ferroptosis of renal tubular epithelial cells through activating Nrf2 signaling pathway.

Zhang J, Zhang G, Jiang L, Qiu D, Wang G, Chen C Cytotechnology. 2024; 76(5):519-531.

PMID: 39188649 PMC: 11344745. DOI: 10.1007/s10616-024-00633-2.

Targeting ferroptosis: a new therapeutic opportunity for kidney diseases.

Long Z, Luo Y, Yu M, Wang X, Zeng L, Yang K Front Immunol. 2024; 15:1435139.

PMID: 39021564 PMC: 11251909. DOI: 10.3389/fimmu.2024.1435139.

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions.

Yang Y, Lin Y, Han Z, Wang B, Zheng W, Wei L Front Immunol. 2024; 15:1440309.

PMID: 38994366 PMC: 11236620. DOI: 10.3389/fimmu.2024.1440309.

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