Infection in Children with Lymphoma in Eastern China: Seroprevalence, Risk Factors and Case-control Studies

Overview

Journal Epidemiol Infect

Publisher Cambridge University Press

Specialties Infectious Diseases
Public Health

Date 2019 Nov 27

PMID 31767044

Citations 3

Authors

Yuhe Duan

Yunlai Zhi

Yusheng Liu

Na Zhou

Fujiang Li

Xiwei Hao

Xiangyan Zhang

Qian Dong

Lili Chen

Affiliations

Soon will be listed here.

Abstract

Epidemiological data for Toxoplasma gondii regarding malignancy have gained increasing attention; however, the information about T. gondii infection among children with malignant lymphoma (ML) in China is unclear. Therefore, 314 children with lymphoma and 314 healthy children, age- and gender-matched, were recruited to estimate the seroprevalence of T. gondii in the participants and identify the risk factors of infection. Blood samples from all participants were collected and examined for T. gondii IgG and IgM antibodies using ELISA. The results showed that the overall seroprevalence of T. gondii antibodies (including IgG and/or IgM) in ML patients and healthy controls was 19.8% and 9.9%, respectively. Contact with the cats, consumption of oysters and history of chemotherapy were estimated to be the risk factors for T. gondii infection in children with lymphoma by multivariable logistic regression analysis, whereas in healthy children, contact with cats and consumption of oysters were the risk factors. Moreover, among various histological types of lymphoma, individuals with NK/T-cell lymphoma, B-small lymphocytic lymphoma, marginal zone B-lymphoma and Hodgkin's lymphoma had a higher seroprevalence than healthy controls (P < 0.05). These findings indicated the high prevalence of T. gondii infection in children with lymphoma, and hence, efforts should be performed to evaluate the effect of the infection further in lymphoma patients.

Citing Articles

Seroprevalence of Anti- Antibodies among Patients with Cancer at Hiwa Cancer Hospital in Sulaimani City, Kurdistan Region, Iraq.

Mohammed L, Amin A, Mohammed R, Mohammed S, Ahmed L, Ahmed V Iran J Parasitol. 2024; 18(4):526-534.

PMID: 38169672 PMC: 10758079. DOI: 10.18502/ijpa.v18i4.14261.

Seroprevalence of Toxoplasma gondii infection among patients of a tertiary hospital in Guangzhou, Guangdong province, PR China.

Guan Y, Sun X, Chen S, Zhu X, Zeng Z, Lu H PLoS One. 2023; 18(7):e0286430.

PMID: 37428723 PMC: 10332624. DOI: 10.1371/journal.pone.0286430.

Increased Risk of Infection in Patients with Colorectal Cancer in Eastern China: Seroprevalence, Risk Factors, and a Case-Control Study.

Yu Y, Guo D, Qu T, Zhao S, Xu C, Wang L Biomed Res Int. 2020; 2020:2539482.

PMID: 33083457 PMC: 7563061. DOI: 10.1155/2020/2539482.

References

Dubey J . Toxoplasmosis - a waterborne zoonosis. Vet Parasitol. 2004; 126(1-2):57-72. DOI: 10.1016/j.vetpar.2004.09.005. View

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M . Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2014; 136(5):E359-86. DOI: 10.1002/ijc.29210. View

Hashiguchi J, Onozawa M, Naka T, Hatanaka K, Shiratori S, Sugita J . Re-infection of Toxoplasma gondii after HSCT presenting lymphadenopathy resembling recurrence of lymphoma. Transpl Infect Dis. 2018; 20(3):e12892. DOI: 10.1111/tid.12892. View

Hoppe R, Advani R, Ai W, Ambinder R, Bello C, Bierman P . Hodgkin lymphoma. J Natl Compr Canc Netw. 2011; 9(9):1020-58. DOI: 10.6004/jnccn.2011.0086. View

. [Possible interactions between Toxoplasma gondii infection and the presence of non-Hodgkin's lymphoma]. Rev Esp Oncol. 1984; 31(2):237-45. View

Zhou N, Fu H, Wang Z, Shi H, Yu Y, Qu T . Seroprevalence and risk factors of infection in children with leukemia in Shandong Province, Eastern China: a case-control prospective study. PeerJ. 2019; 7:e6604. PMC: 6420808. DOI: 10.7717/peerj.6604. View

Shen D, Herbort C, Tuaillon N, Buggage R, Egwuagu C, Chan C . Detection of Toxoplasma gondii DNA in primary intraocular B-cell lymphoma. Mod Pathol. 2001; 14(10):995-9. DOI: 10.1038/modpathol.3880424. View

Liesenfeld O, Montoya J, Kinney S, Press C, Remington J . Effect of testing for IgG avidity in the diagnosis of Toxoplasma gondii infection in pregnant women: experience in a US reference laboratory. J Infect Dis. 2001; 183(8):1248-53. DOI: 10.1086/319672. View

Mordue D, Monroy F, La Regina M, Dinarello C, Sibley L . Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines. J Immunol. 2001; 167(8):4574-84. DOI: 10.4049/jimmunol.167.8.4574. View

10.

Cong W, Liu G, Meng Q, Dong W, Qin S, Zhang F . Toxoplasma gondii infection in cancer patients: prevalence, risk factors, genotypes and association with clinical diagnosis. Cancer Lett. 2015; 359(2):307-13. DOI: 10.1016/j.canlet.2015.01.036. View

11.

Herold M, Kuhne R, Vosberg M, Ostheeren-Michaelis S, Vogt P, Karrer U . Disseminated toxoplasmosis in a patient with non-Hodgkin lymphoma. Infection. 2009; 37(6):551-4. DOI: 10.1007/s15010-009-9007-5. View

12.

da Silva A, Tonin A, Thorstenberg M, Leal D, Fighera R, Flores M . Relationship between butyrylcholinesterase activity and liver injury in mice acute infected with Toxoplasma gondii. Pathol Res Pract. 2013; 209(2):95-8. DOI: 10.1016/j.prp.2012.10.007. View

13.

Li Y, Xin H, Zhang X, Wei C, Duan Y, Wang H . Infection in Diabetes Mellitus Patients in China: Seroprevalence, Risk Factors, and Case-Control Studies. Biomed Res Int. 2019; 2018:4723739. PMC: 6312584. DOI: 10.1155/2018/4723739. View

14.

He J, Ma J, Wang J, Xu M, Zhu X . Analysis of miRNA expression profiling in mouse spleen affected by acute Toxoplasma gondii infection. Infect Genet Evol. 2015; 37:137-42. DOI: 10.1016/j.meegid.2015.11.005. View

15.

Alvarado-Esquivel C, Sanchez-Anguiano L, Hernandez-Tinoco J, Ramos-Nevarez A, Estrada-Martinez S, Cerrillo-Soto S . Association between Toxoplasma gondii infection and history of blood transfusion: a case-control seroprevalence study. J Int Med Res. 2018; 46(4):1626-1633. PMC: 6091851. DOI: 10.1177/0300060518757928. View

16.

Nimir A, Othman A, Ee S, Musa Z, Majid I, Kamarudin Z . Latent toxoplasmosis in patients with different malignancy: a hospital based study. J Clin Med Res. 2011; 2(3):117-20. PMC: 3104645. DOI: 10.4021/jocmr2010.06.375w. View

17.

Ferreira M, Borges A . Some aspects of protozoan infections in immunocompromised patients- a review. Mem Inst Oswaldo Cruz. 2002; 97(4):443-57. DOI: 10.1590/s0074-02762002000400001. View

18.

Zhou N, Zhang X, Li Y, Wang L, Wang L, Cong W . Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case-control prospective study. Epidemiol Infect. 2018; 146(15):1891-1895. PMC: 6452986. DOI: 10.1017/S0950268818001978. View

19.

Alvarado-Esquivel C, Liesenfeld O, Torres-Castorena A, Estrada-Martinez S, Urbina-Alvarez J, Ramos-de la Rocha M . Seroepidemiology of Toxoplasma gondii infection in patients with vision and hearing impairments, cancer, HIV, or undergoing hemodialysis in Durango, Mexico. J Parasitol. 2010; 96(3):505-8. DOI: 10.1645/GE-2378.1. View

20.

Scerra S, Coignard-Biehler H, Lanternier F, Suarez F, Charlier-Woerther C, Bougnoux M . Disseminated toxoplasmosis in non-allografted patients with hematologic malignancies: report of two cases and literature review. Eur J Clin Microbiol Infect Dis. 2013; 32(10):1259-68. DOI: 10.1007/s10096-013-1879-8. View