Exercise Exacerbates the Transcriptional Profile of Hypoxia, Oxidative Stress and Inflammation in Rats with Adjuvant-Induced Arthritis

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2019 Nov 27

PMID 31766745

Citations 4

Authors

Susana Aidee Gonzalez-Chavez

Celia Maria Quinonez-Flores

Gerardo Pavel Espino-Solis

Jose Angel Vazquez-Contreras

Cesar Pacheco-Tena

Affiliations

Soon will be listed here.

Abstract

Physical exercise (PE) is recommended for Rheumatoid Arthritis (RA), but the molecular and biological mechanisms that impact the inflammatory process and joint destruction in RA remain unknown. The objective of this study was to evaluate the effect of PE on the histological and transcriptional changes in the joints of adjuvant-induced arthritis (AIA) rat model. AIA rats were subjected to PE on a treadmill for eight weeks. The joints were subjected to histological and microarray analysis. The differentially expressed genes (DEGs) by PE in the arthritic rats were obtained from the microarray. The bioinformatic analysis allowed the association of these genes in biological processes and signaling pathways. PE induced the differential expression of 719 genes. The DEGs were significantly associated with pathogenic mechanisms in RA, including HIF-1, VEGF, PI3-Akt, and Jak-STAT signaling pathways, as well as response to oxidative stress and inflammatory response. At a histological level, PE exacerbated joint inflammatory infiltrate and tissue destruction. The PE exacerbated the stressed joint environment aggravating the inflammatory process, the hypoxia, and the oxidative stress, conditions described as detrimental in the RA joints. Research on the effect of PE on the pathogenesis process of RA is still necessary for animal models and human.

Citing Articles

Complete Freund's Adjuvant Induces a Fibroblast-like Synoviocytes (FLS) Metabolic and Migratory Phenotype in Resident Fibroblasts of the Inoculated Footpad at the Earliest Stage of Adjuvant-Induced Arthritis.

Gonzalez-Chavez S, Chaparro-Barrera E, Alvarado-Jaquez M, Cuevas-Martinez R, Ochoa-Albiztegui R, Pacheco-Tena C Cells. 2023; 12(6).

PMID: 36980183 PMC: 10047124. DOI: 10.3390/cells12060842.

Low-Intensity Physical Exercise Decreases Inflammation and Joint Damage in the Preclinical Phase of a Rheumatoid Arthritis Murine Model.

Gonzalez-Chavez S, Lopez-Loeza S, Acosta-Jimenez S, Cuevas-Martinez R, Pacheco-Silva C, Chaparro-Barrera E Biomolecules. 2023; 13(3).

PMID: 36979423 PMC: 10046494. DOI: 10.3390/biom13030488.

Mitochondrial Dysfunction and Oxidative Stress in Rheumatoid Arthritis.

Lopez-Armada M, Fernandez-Rodriguez J, Blanco F Antioxidants (Basel). 2022; 11(6).

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Myeloid IPMK promotes the resolution of serum transfer-induced arthritis in mice.

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