Natural Antibacterial Reagents (, Propolis, and Hinokitiol) Loaded into Poly[()-3-hydroxybutyrate--()-3-hydroxyhexanoate] Composite Nanofibers for Biomedical Applications

Overview

Journal Nanomaterials (Basel)

Date 2019 Nov 27

PMID 31766678

Citations 9

Authors

Rina Afiani Rebia

Nurul Shaheera Binti Sadon

Toshihisa Tanaka

Affiliations

Soon will be listed here.

Abstract

, propolis, and hinokitiol, as natural antibacterial reagents, were integrated into the poly[()-3-hydroxybutyrate--()-3-hydroxyhexanoate] (PHBH) polymer to produce antibacterial wound dressings, using electrospinning process. The results showed that the fiber diameters and surface morphology of PHBH composite nanofibers were influenced by the addition of ethanol- (EC), methanol- (MC), ethanol-propolis (EP), and ethanol-hinokitiol (EH) at various ratios compared to pristine PHBH nanofibers. From FT-IR, the nanofibrous samples with higher contents of natural antibacterial substances showed the peaks of carboxylic acid, aromatic ring, and tropolone carbon ring from , propolis, and hinokitiol, respectively. Furthermore, the tensile strength of neat PHBH nanofibers was increased from 8.00 ± 0.71 MPa up to 16.35 ± 1.78 MPa by loading of propolis (EP) 7% into PHBH. X-ray analysis explained that the loading of propolis (EP) was also able to increase the crystallinity in PHBH composite nanofibers from 47.0% to 54.5%. The antibacterial results demonstrated that PHBH composite nanofibers containing natural antibacterial products were potent inhibitors against the growth of and , amongst them hinokitiol and propolis proved to be the most effective. Additionally, the release studies displayed that and hinokitiol had faster release from PHBH composite nanofibers in comparison to propolis.

Citing Articles

3D-Printed Poly(3-hydroxybutyrate--3-hydroxyhexanoate)-Cellulose-Based Scaffolds for Biomedical Applications.

Giubilini A, Messori M, Bondioli F, Minetola P, Iuliano L, Nystrom G Biomacromolecules. 2023; 24(9):3961-3971.

PMID: 37589321 PMC: 10498448. DOI: 10.1021/acs.biomac.3c00263.

Hinokitiol inhibits by interfering with the cell membrane and cell wall.

Meng F, Liu X, Li C, Peng X, Wang Q, Xu Q Front Microbiol. 2023; 14:1132042.

PMID: 37113218 PMC: 10128913. DOI: 10.3389/fmicb.2023.1132042.

Electrospun Poly (Vinyl Alcohol) Nanofibrous Mat Loaded with Green Propolis Extract, Chitosan and Nystatin as an Innovative Wound Dressing Material.

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PMID: 36061220 PMC: 9427432. DOI: 10.1007/s12247-022-09681-7.

Nonwoven Releasing Propolis as a Potential New Wound Healing Method-A Review.

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Advantages of Additive Manufacturing for Biomedical Applications of Polyhydroxyalkanoates.

Giubilini A, Bondioli F, Messori M, Nystrom G, Siqueira G Bioengineering (Basel). 2021; 8(2).

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