The Antioxidant Rich Active Principles of Sp. Controls Haloalkane Xenobiotic Induced Hepatic Damage in Murine Model

Overview

Journal Saudi J Biol Sci

Specialty Biology

Date 2019 Nov 26

PMID 31762623

Citations 1

Authors

Pallab Kar

Somit Dutta

Arnab Kumar Chakraborty

Ayan Roy

Subhajit Sen

Anoop Kumar

Joongku Lee

Tapas Kumar Chaudhuri

Arnab Sen

Affiliations

Soon will be listed here.

Abstract

is a plant with potent antioxidant activity and has been frequently employed as a traditional remedy against bronchitis, asthma, liver and stomach disorders. Three species of genus namely and (Syn. ) were investigated for their possible activity against oxidative stress induced liver injury. Apart from generation of Reactive Oxygen Species (ROS) in the WRL-68 cell line (human hepatic cell line), and antioxidant assays were also assessed. Features of immune cell proliferation (MTT) were analyzed thoroughly. Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier Transform Infrared Spectroscopy (FTIR) analyses have been performed to identify the active biological compounds. These active biological compounds were further subjected to molecular docking. The antioxidant activity of three sp. was significantly high in DPPH, nitric oxide, hydroxyl radical and hydrogen peroxide etc. Biochemical parameters like catalase, superoxide dismutase (SOD) and reduced glutathione (GSH) were generated in excess due to CCl administration, which was ameliorated by treating with extract. The phytochemical 24,25-Dihydroxyvitamin D shows excellent binding affinity in Autodock Vina. The present study provided convincing evidences that and showed good result but performed better by almost all means.

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PMID: 36683730 PMC: 9838539. DOI: 10.1007/s40089-023-00392-6.

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