A System Composed of Vanadium(IV) Disulfide Quantum Dots and Molybdenum(IV) Disulfide Nanosheets for Use in an Aptamer-based Fluorometric Tetracycline Assay

Overview

Journal Mikrochim Acta

Specialties Biotechnology
Chemistry

Date 2019 Nov 25

PMID 31760474

Citations 5

Authors

Xiaohan Ma

Cuicui Du

Jinling Zhang

Mengxiang Shang

Wenbo Song

Affiliations

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Abstract

A system composed of vanadium(IV) disulfide quantum dots (VS QDs) and molybdenum(IV) disulfide (MoS) nanosheets for use in an aptamer-based fluorometric tetracycline assay was developed. The tetracycline (TET) aptamer was first immobilzed on the VS QDs with a typical size of 3 nm. The blue fluorescence of the VS QDs (labeled with aptamer) with emission maxima at 448 nm (under excitation at 360 nm) was subsequently quenched by MoS nanosheets. If TET is recognized by the aptamer, the VS QDs drift away from the basal plane of the MoS nanosheets. This generated "turn-on" fluorescence of the VS QDs. A VS QD/MoS nanosheet-based fluorometric TET aptasensor was thus constructed. Selective and sensitive TET bioanalysis was realized in a linear range of 1 to 250 ng mL. The detection limit was 0.06 ng mL. Its applicability of determination of TET in milk samples has been demonstrated. Graphical abstractSchematic representation of the aptamer-based fluorometric tetracycline assay.

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