MicroRNAs and Exosomes: Key Players in HIV Pathogenesis

Overview

Journal HIV Med

Publisher Wiley

Specialty Infectious Diseases

Date 2019 Nov 23

PMID 31756034

Citations 35

Authors

J Sadri Nahand

F Bokharaei-Salim

M Karimzadeh

M Moghoofei

S Karampoor

H R Mirzaei

A Tabibzadeh

A Jafari

A Ghaderi

Z Asemi

H Mirzaei

M R Hamblin

Affiliations

Soon will be listed here.

Abstract

Objectives: HIV infection is well known to cause impairment of the human immune system, and until recently was a leading cause of death. It has been shown that T lymphocytes are the main targets of HIV. The virus inactivates T lymphocytes by interfering with a wide range of cellular and molecular targets, leading to suppression of the immune system. The objective of this review is to investigate to what extent microRNAs (miRNAs) are involved in HIV pathogenesis.

Methods: The scientific literature (Pubmed and Google scholar) for the period 1988-2019 was searched.

Results: Mounting evidence has revealed that miRNAs are involved in viral replication and immune response, whether by direct targeting of viral transcripts or through indirect modulation of virus-related host pathways. In addition, exosomes have been found to act as nanoscale carriers involved in HIV pathogenesis. These nanovehicles target their cargos (i.e. DNA, RNA, viral proteins and miRNAs) leading to alteration of the behaviour of recipient cells.

Conclusions: miRNAs and exosomes are important players in HIV pathogenesis. Additionally, there are potential diagnostic applications of miRNAs as biomarkers in HIV infection.

Citing Articles

Bridging brain and blood: a prospective view on neuroimaging-exosome correlations in HIV-associated neurocognitive disorders.

Luo H, Chen J, Liu J, Wang W, Hou C, Jiang X Front Neurol. 2025; 15():1479272.

PMID: 39839878 PMC: 11745957. DOI: 10.3389/fneur.2024.1479272.

Exosomes and microRNAs as mediators of the exercise.

Li H, Liu G, Wang B, Momeni M Eur J Med Res. 2025; 30(1):38.

PMID: 39828711 PMC: 11742998. DOI: 10.1186/s40001-025-02273-4.

A State-of-the-Art Review on the Recent Advances in Exosomes in Oncogenic Virus.

Ebrahimi F, Modaresi Movahedi A, Sabbaghian M, Poortahmasebi V Health Sci Rep. 2024; 7(11):e70196.

PMID: 39558933 PMC: 11570872. DOI: 10.1002/hsr2.70196.

MicroRNA as Key Players in Hepatocellular Carcinoma: Insights into Their Role in Metastasis.

Saadh M, Hussain Q, Alazzawi T, Fahdil A, Athab Z, Yarmukhamedov B Biochem Genet. 2024; .

PMID: 39103713 DOI: 10.1007/s10528-024-10897-0.

Exosomal miR-7-25207 Increases Subgroup J Avian Leukosis Virus Titers by Targeting the Akt-CyclinQ1 and PRC1-YAF2 Dual Pathways.

Zeng X, Liu T, Tang S, Dong X, Li Y, Liao L Microorganisms. 2024; 12(7).

PMID: 39065263 PMC: 11279298. DOI: 10.3390/microorganisms12071495.

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