Neurochemical Organization of the Ventral Striatum's Olfactory Tubercle

Overview

Journal J Neurochem

Specialties Chemistry
Neurology

Date 2019 Nov 23

PMID 31755104

Citations 18

Authors

Hillary L Cansler

Katherine N Wright

Lucas A Stetzik

Daniel W Wesson

Affiliations

Soon will be listed here.

Abstract

The ventral striatum is a collection of brain structures, including the nucleus accumbens, ventral pallidum and the olfactory tubercle (OT). While much attention has been devoted to the nucleus accumbens, a comprehensive understanding of the ventral striatum and its contributions to neurological diseases requires an appreciation for the complex neurochemical makeup of the ventral striatum's other components. This review summarizes the rich neurochemical composition of the OT, including the neurotransmitters, neuromodulators and hormones present. We also address the receptors and transporters involved in each system as well as their putative functional roles. Finally, we end with briefly reviewing select literature regarding neurochemical changes in the OT in the context of neurological disorders, specifically neurodegenerative disorders. By overviewing the vast literature on the neurochemical composition of the OT, this review will serve to aid future research into the neurobiology of the ventral striatum.

Citing Articles

Virtual anatomical atlas of the deep brain nuclei.

Sevgi U, Gungor A, Erol G, Canbolat C, Middlebrooks E, Sonmez O Neurosurg Rev. 2024; 47(1):849.

PMID: 39607537 DOI: 10.1007/s10143-024-03096-3.

Hyperactive mTORC1 in striatum dysregulates dopamine receptor expression and odor preference behavior.

Chen L, Saito R, Noda-Narita S, Kassai H, Aiba A Front Neurosci. 2024; 18:1461178.

PMID: 39280263 PMC: 11392874. DOI: 10.3389/fnins.2024.1461178.

Gestational VPA exposure reduces the density of juxtapositions between TH+ axons and calretinin or calbindin expressing cells in the ventrobasal forebrain of neonatal mice.

Finszter C, Kemecsei R, Zachar G, Adam A, Csillag A Front Neuroanat. 2024; 18:1426042.

PMID: 39026519 PMC: 11254666. DOI: 10.3389/fnana.2024.1426042.

Connectivity of the olfactory tubercle: inputs, outputs, and their plasticity.

Yamaguchi M Front Neural Circuits. 2024; 18:1423505.

PMID: 38841557 PMC: 11150588. DOI: 10.3389/fncir.2024.1423505.

Structural Connectivity between Olfactory Tubercle and Ventrolateral Periaqueductal Gray Implicated in Human Feeding Behavior.

Zhou G, Lane G, Kahnt T, Zelano C J Neurosci. 2024; 44(25).

PMID: 38755004 PMC: 11209663. DOI: 10.1523/JNEUROSCI.2342-23.2024.

References

Mucha R, Herz A . Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning. Psychopharmacology (Berl). 1985; 86(3):274-80. DOI: 10.1007/BF00432213. View

Gerfen C, Engber T, Mahan L, Susel Z, Chase T, Monsma Jr F . D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science. 1990; 250(4986):1429-32. DOI: 10.1126/science.2147780. View

Trudeau L, El Mestikawy S . Glutamate Cotransmission in Cholinergic, GABAergic and Monoamine Systems: Contrasts and Commonalities. Front Neural Circuits. 2019; 12:113. PMC: 6305298. DOI: 10.3389/fncir.2018.00113. View

Hammock E, Levitt P . Oxytocin receptor ligand binding in embryonic tissue and postnatal brain development of the C57BL/6J mouse. Front Behav Neurosci. 2013; 7:195. PMC: 3858721. DOI: 10.3389/fnbeh.2013.00195. View

Carriero G, Uva L, Gnatkovsky V, de Curtis M . Distribution of the olfactory fiber input into the olfactory tubercle of the in vitro isolated guinea pig brain. J Neurophysiol. 2008; 101(3):1613-9. DOI: 10.1152/jn.90792.2008. View

De Marchis S, Fasolo A, Puche A . Subventricular zone-derived neuronal progenitors migrate into the subcortical forebrain of postnatal mice. J Comp Neurol. 2004; 476(3):290-300. DOI: 10.1002/cne.20217. View

Hadley J, Halliwell J . Serotonin modulates glutamatergic transmission in the rat olfactory tubercle. Eur J Neurosci. 2010; 31(4):659-72. DOI: 10.1111/j.1460-9568.2010.07084.x. View

Gilmor M, Nash N, Roghani A, EDWARDS R, Yi H, Hersch S . Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles. J Neurosci. 1996; 16(7):2179-90. PMC: 6578528. View

Carter M, Yizhar O, Chikahisa S, Nguyen H, Adamantidis A, Nishino S . Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci. 2010; 13(12):1526-33. PMC: 3174240. DOI: 10.1038/nn.2682. View

10.

Wess J . Molecular biology of muscarinic acetylcholine receptors. Crit Rev Neurobiol. 1996; 10(1):69-99. DOI: 10.1615/critrevneurobiol.v10.i1.40. View

11.

Durkin M, Gunwaldsen C, Borowsky B, Jones K, Branchek T . An in situ hybridization study of the distribution of the GABA(B2) protein mRNA in the rat CNS. Brain Res Mol Brain Res. 1999; 71(2):185-200. DOI: 10.1016/s0169-328x(99)00182-5. View

12.

Alheid G, Heimer L . New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: the striatopallidal, amygdaloid, and corticopetal components of substantia innominata. Neuroscience. 1988; 27(1):1-39. DOI: 10.1016/0306-4522(88)90217-5. View

13.

Lin J, Chung K, de Castro D, Funk G, Lipski J . Effects of muscarinic acetylcholine receptor activation on membrane currents and intracellular messengers in medium spiny neurones of the rat striatum. Eur J Neurosci. 2004; 20(5):1219-30. DOI: 10.1111/j.1460-9568.2004.03576.x. View

14.

Lobo M, Karsten S, Gray M, Geschwind D, Yang X . FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains. Nat Neurosci. 2006; 9(3):443-52. DOI: 10.1038/nn1654. View

15.

Funada M, Suzuki T, Narita M, Misawa M, Nagase H . Blockade of morphine reward through the activation of kappa-opioid receptors in mice. Neuropharmacology. 1993; 32(12):1315-23. DOI: 10.1016/0028-3908(93)90026-y. View

16.

Nicholas A, Pieribone V, Hokfelt T . Cellular localization of messenger RNA for beta-1 and beta-2 adrenergic receptors in rat brain: an in situ hybridization study. Neuroscience. 1993; 56(4):1023-39. DOI: 10.1016/0306-4522(93)90148-9. View

17.

Murphy C . Olfactory and other sensory impairments in Alzheimer disease. Nat Rev Neurol. 2018; 15(1):11-24. DOI: 10.1038/s41582-018-0097-5. View

18.

Laux A, Muller A, Miehe M, Dirrig-Grosch S, Deloulme J, Delalande F . Mapping of endogenous morphine-like compounds in the adult mouse brain: Evidence of their localization in astrocytes and GABAergic cells. J Comp Neurol. 2011; 519(12):2390-416. DOI: 10.1002/cne.22633. View

19.

de Vente J, Hopkins D, Markerink-van Ittersum M, Steinbusch H . Nitric oxide-mediated cGMP production in the islands of Calleja in the rat. Brain Res. 1998; 789(1):175-8. DOI: 10.1016/s0006-8993(98)00099-7. View

20.

Giardino L, Zanni M, Bettelli C, Savina M, Calza L . Regulation of glutamic acid decarboxylase mRNA expression in rat brain after sertraline treatment. Eur J Pharmacol. 1996; 312(2):183-7. DOI: 10.1016/0014-2999(96)00588-2. View