Hepatitis B and HIV-1 2019 IAS Cure Forum: Lessons and Benefits from Interdisciplinary Research

Overview

Journal J Virus Erad

Date 2019 Nov 23

PMID 31754448

Authors

M Paximadis

S Perez Patrigeon

R Rajasuriar

R Tatoud

E Scully

P Arbuthnot

Affiliations

Soon will be listed here.

References

Boni C, Barili V, Acerbi G, Rossi M, Vecchi A, Laccabue D . HBV Immune-Therapy: From Molecular Mechanisms to Clinical Applications. Int J Mol Sci. 2019; 20(11). PMC: 6600394. DOI: 10.3390/ijms20112754. View

Tebas P, Stein D, Tang W, Frank I, Wang S, Lee G . Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med. 2014; 370(10):901-10. PMC: 4084652. DOI: 10.1056/NEJMoa1300662. View

Naran K, Nundalall T, Chetty S, Barth S . Principles of Immunotherapy: Implications for Treatment Strategies in Cancer and Infectious Diseases. Front Microbiol. 2019; 9:3158. PMC: 6308495. DOI: 10.3389/fmicb.2018.03158. View

Cohn L, da Silva I, Valieris R, Huang A, Lorenzi J, Cohen Y . Clonal CD4 T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation. Nat Med. 2018; 24(5):604-609. PMC: 5972543. DOI: 10.1038/s41591-018-0017-7. View

Lu C, Pai J, Nogueira L, Mendoza P, Gruell H, Oliveira T . Relationship between intact HIV-1 proviruses in circulating CD4 T cells and rebound viruses emerging during treatment interruption. Proc Natl Acad Sci U S A. 2018; 115(48):E11341-E11348. PMC: 6275529. DOI: 10.1073/pnas.1813512115. View

Cohn L, Silva I, Oliveira T, Rosales R, Parrish E, Learn G . HIV-1 integration landscape during latent and active infection. Cell. 2015; 160(3):420-32. PMC: 4371550. DOI: 10.1016/j.cell.2015.01.020. View

Liddy N, Bossi G, Adams K, Lissina A, Mahon T, Hassan N . Monoclonal TCR-redirected tumor cell killing. Nat Med. 2012; 18(6):980-7. DOI: 10.1038/nm.2764. View

Lopatin U, Wolfgang G, Tumas D, Frey C, Ohmstede C, Hesselgesser J . Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist. Antivir Ther. 2013; 18(3):409-18. DOI: 10.3851/IMP2548. View

Decorsiere A, Mueller H, van Breugel P, Abdul F, Gerossier L, Beran R . Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor. Nature. 2016; 531(7594):386-9. DOI: 10.1038/nature17170. View

10.

Ferrari G, Haynes B, Koenig S, Nordstrom J, Margolis D, Tomaras G . Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection. Nat Rev Drug Discov. 2016; 15(12):823-834. PMC: 5549020. DOI: 10.1038/nrd.2016.173. View

11.

Hiener B, Horsburgh B, Eden J, Barton K, Schlub T, Lee E . Identification of Genetically Intact HIV-1 Proviruses in Specific CD4 T Cells from Effectively Treated Participants. Cell Rep. 2017; 21(3):813-822. PMC: 5960642. DOI: 10.1016/j.celrep.2017.09.081. View

12.

Watson D, Moysi E, Valentin A, Bergamaschi C, Devasundaram S, Fortis S . Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes. PLoS Pathog. 2018; 14(2):e1006902. PMC: 5825155. DOI: 10.1371/journal.ppat.1006902. View

13.

Hosmane N, Kwon K, Bruner K, Capoferri A, Beg S, Rosenbloom D . Proliferation of latently infected CD4 T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics. J Exp Med. 2017; 214(4):959-972. PMC: 5379987. DOI: 10.1084/jem.20170193. View

14.

Maude S, Frey N, Shaw P, Aplenc R, Barrett D, Bunin N . Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med. 2014; 371(16):1507-17. PMC: 4267531. DOI: 10.1056/NEJMoa1407222. View

15.

Coffin C, Zhou K, Terrault N . New and Old Biomarkers for Diagnosis and Management of Chronic Hepatitis B Virus Infection. Gastroenterology. 2018; 156(2):355-368.e3. PMC: 6433165. DOI: 10.1053/j.gastro.2018.11.037. View

16.

Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X . Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science. 2014; 343(6176):1221-8. PMC: 6309542. DOI: 10.1126/science.1243462. View

17.

Harper J, Adams K, Bossi G, Wright D, Stacey A, Bedke N . An approved in vitro approach to preclinical safety and efficacy evaluation of engineered T cell receptor anti-CD3 bispecific (ImmTAC) molecules. PLoS One. 2018; 13(10):e0205491. PMC: 6188753. DOI: 10.1371/journal.pone.0205491. View

18.

Cardenas M, Yu W, Beguelin W, Teater M, Geng H, Goldstein R . Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma. J Clin Invest. 2016; 126(9):3351-62. PMC: 5004937. DOI: 10.1172/JCI85795. View

19.

Gaebler C, Lorenzi J, Oliveira T, Nogueira L, Ramos V, Lu C . Combination of quadruplex qPCR and next-generation sequencing for qualitative and quantitative analysis of the HIV-1 latent reservoir. J Exp Med. 2019; 216(10):2253-2264. PMC: 6781006. DOI: 10.1084/jem.20190896. View

20.

Schurich A, Pallett L, Lubowiecki M, Singh H, Gill U, Kennedy P . The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cells. PLoS Pathog. 2013; 9(3):e1003208. PMC: 3597507. DOI: 10.1371/journal.ppat.1003208. View