Surgical Considerations and Systemic Therapy of Melanoma

Overview

Journal Surg Clin North Am

Specialty General Surgery

Date 2019 Nov 23

PMID 31753109

Citations 8

Authors

Adriana C Gamboa

Michael Lowe

Melinda L Yushak

Keith A Delman

Affiliations

Soon will be listed here.

Abstract

Recent advances in effective medical therapies have markedly improved the prognosis for patients with advanced melanoma. This article aims to highlight the current era of integrated multidisciplinary care of patients with advanced melanoma by outlining current approved therapies, including immunotherapy, targeted therapy, radiation therapy, and other strategies used in both the adjuvant and the neoadjuvant setting as well as the evolving role of surgical intervention in the changing landscape of advanced melanoma.

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References

Yao K, Hsueh E, Essner R, Foshag L, Wanek L, Morton D . Is sentinel lymph node mapping indicated for isolated local and in-transit recurrent melanoma?. Ann Surg. 2003; 238(5):743-7. PMC: 1356154. DOI: 10.1097/01.sla.0000094440.50547.1d. View

Ollila D, Essner R, Wanek L, Morton D . Surgical resection for melanoma metastatic to the gastrointestinal tract. Arch Surg. 1996; 131(9):975-9; 979-80. DOI: 10.1001/archsurg.1996.01430210073013. View

Mittendorf E, Lim S, Schacherer C, Lucci A, Cormier J, Mansfield P . Melanoma adrenal metastasis: natural history and surgical management. Am J Surg. 2008; 195(3):363-8. DOI: 10.1016/j.amjsurg.2007.12.018. View

Sosman J, Kim K, Schuchter L, Gonzalez R, Pavlick A, Weber J . Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med. 2012; 366(8):707-14. PMC: 3724515. DOI: 10.1056/NEJMoa1112302. View

Andtbacka R, Kaufman H, Collichio F, Amatruda T, Senzer N, Chesney J . Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma. J Clin Oncol. 2015; 33(25):2780-8. DOI: 10.1200/JCO.2014.58.3377. View

Amaria R, Prieto P, Tetzlaff M, Reuben A, Andrews M, Ross M . Neoadjuvant plus adjuvant dabrafenib and trametinib versus standard of care in patients with high-risk, surgically resectable melanoma: a single-centre, open-label, randomised, phase 2 trial. Lancet Oncol. 2018; 19(2):181-193. DOI: 10.1016/S1470-2045(18)30015-9. View

Henderson M, Burmeister B, Ainslie J, Fisher R, Di Iulio J, Smithers B . Adjuvant lymph-node field radiotherapy versus observation only in patients with melanoma at high risk of further lymph-node field relapse after lymphadenectomy (ANZMTG 01.02/TROG 02.01): 6-year follow-up of a phase 3, randomised controlled trial. Lancet Oncol. 2015; 16(9):1049-1060. DOI: 10.1016/S1470-2045(15)00187-4. View

Hodi F, ODay S, Mcdermott D, Weber R, Sosman J, Haanen J . Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010; 363(8):711-23. PMC: 3549297. DOI: 10.1056/NEJMoa1003466. View

Ghazawi F, Cyr J, Darwich R, Le M, Rahme E, Moreau L . Cutaneous malignant melanoma incidence and mortality trends in Canada: A comprehensive population-based study. J Am Acad Dermatol. 2018; 80(2):448-459. DOI: 10.1016/j.jaad.2018.07.041. View

10.

Weber J, DAngelo S, Minor D, Hodi F, Gutzmer R, Neyns B . Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2015; 16(4):375-84. DOI: 10.1016/S1470-2045(15)70076-8. View

11.

Rule W, Allred J, Pockaj B, Markovic S, DiCaudo D, Erickson L . Results of NCCTG N0275 (Alliance) - a phase II trial evaluating resection followed by adjuvant radiation therapy for patients with desmoplastic melanoma. Cancer Med. 2016; 5(8):1890-6. PMC: 4971918. DOI: 10.1002/cam4.783. View

12.

Sosman J, Moon J, Tuthill R, Warneke J, Vetto J, Redman B . A phase 2 trial of complete resection for stage IV melanoma: results of Southwest Oncology Group Clinical Trial S9430. Cancer. 2011; 117(20):4740-06. PMC: 3129414. DOI: 10.1002/cncr.26111. View

13.

Kirkwood J, Strawderman M, Ernstoff M, Smith T, Borden E, Blum R . Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. J Clin Oncol. 1996; 14(1):7-17. DOI: 10.1200/JCO.1996.14.1.7. View

14.

Ott P, Hu Z, Keskin D, Shukla S, Sun J, Bozym D . An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2017; 547(7662):217-221. PMC: 5577644. DOI: 10.1038/nature22991. View

15.

Pollock P, Harper U, Hansen K, Yudt L, Stark M, Robbins C . High frequency of BRAF mutations in nevi. Nat Genet. 2002; 33(1):19-20. DOI: 10.1038/ng1054. View

16.

Faries M, Mozzillo N, Kashani-Sabet M, Thompson J, Kelley M, DeConti R . Long-Term Survival after Complete Surgical Resection and Adjuvant Immunotherapy for Distant Melanoma Metastases. Ann Surg Oncol. 2017; 24(13):3991-4000. DOI: 10.1245/s10434-017-6072-3. View

17.

Karakousis C, Velez A, Driscoll D, Takita H . Metastasectomy in malignant melanoma. Surgery. 1994; 115(3):295-302. View

18.

Siegel R, Miller K, Jemal A . Cancer statistics, 2018. CA Cancer J Clin. 2018; 68(1):7-30. DOI: 10.3322/caac.21442. View

19.

Munoz-Couselo E, Soberino Garcia J, Perez-Garcia J, Cebrian V, Castan J . Recent advances in the treatment of melanoma with BRAF and MEK inhibitors. Ann Transl Med. 2015; 3(15):207. PMC: 4583602. DOI: 10.3978/j.issn.2305-5839.2015.05.13. View

20.

Agrawal S, Yao T, Coit D . Surgery for melanoma metastatic to the gastrointestinal tract. Ann Surg Oncol. 1999; 6(4):336-44. DOI: 10.1007/s10434-999-0336-5. View