Rare Crystalline Nephropathy Leading to Acute Graft Dysfunction: a Case Report

Overview

Journal BMC Nephrol

Publisher Biomed Central

Specialty Nephrology

Date 2019 Nov 23

PMID 31752739

Citations 3

Authors

Sahil Bagai

Dinesh Khullar

Bhavna Bansal

Affiliations

Soon will be listed here.

Abstract

Background: Adenine phosphoribosyl transferase (APRT) deficiency is a rare genetic form of kidney stones and/or kidney failure characterized by intratubular precipitation of 2,8 dihydroxyadenine crystals. Early diagnosis and prompt management can completely reverse the kidney injury.

Case Presentation: 44 year old Indian male, renal transplant recipient got admitted with acute graft dysfunction. Graft biopsy showed light brown refractile intratubular crystals with surrounding giant cell reaction, consistent with APRT deficiency. Patient improved after receiving allopurinol and hydration.

Conclusion: APRT forms a reversible cause of crystalline nephropathy. High index of suspicion is required for the correct diagnosis as timely diagnosis has therapeutic implications.

Citing Articles

Adenine phosphoribosyltransferase (APRT) deficiency: an increasingly recognized disease.

Leow E, Ganesan I, Chong S, Yap C, Chao S, Wang F Int Urol Nephrol. 2025; .

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Adenine phosphoribosyl transferase deficiency leads to renal allograft dysfunction in kidney transplant recipients: a systematic review.

Rashid I, Verma A, Tiwari P, DCruz S J Bras Nefrol. 2022; 44(3):403-416.

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Recurrence of 2,8-dihydroxyadenine Crystalline Nephropathy in a Kidney Transplant Recipient: A Case Report and Literature Review.

Cheng Y, Guo L, Wang M, Chen J, Wang R Intern Med. 2021; 60(16):2651-2657.

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Calcium oxalate crystal deposition in the kidney: identification, causes and consequences.

Geraghty R, Wood K, Sayer J Urolithiasis. 2020; 48(5):377-384.

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