HBV Infection in HIV-Driven Immune Suppression

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2019 Nov 23

PMID 31752284

Citations 16

Authors

Loredana Sarmati

Vincenzo Malagnino

Affiliations

Soon will be listed here.

Abstract

Worldwide, approximately 10% of all human immunodeficiency virus (HIV)-infected people are also chronically coinfected with hepatitis B virus (HBV). HBV infection has a poor prognosis in HIV-positive people and has been documented by an increased risk of developing chronic HBV infection (CHB), progression to liver fibrosis and end-stage liver disease (ESLD) and evolution of hepatocellular carcinoma (HCC). Furthermore, in HIV patients, HBV-resolved infection is often associated with the appearance of HBV-DNA, which configures occult HBV infection (OBI) as a condition to be explored in coinfected patients. In this narrative review we summarize the main aspects of HBV infection in HIV-positive patients, emphasizing the importance of carefully considering the coinfected patient in the context of therapeutic strategies of antiretroviral therapy.

Citing Articles

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