Quantification of Skeletal Muscle Mass: Sarcopenia As a Marker of Overall Health in Children and Adults

Overview

Journal Pediatr Radiol

Specialty Pediatrics

Date 2019 Nov 21

PMID 31745597

Citations 22

Authors

Leah A Gilligan

Alexander J Towbin

Jonathan R Dillman

Elanchezhian Somasundaram

Andrew T Trout

Affiliations

Soon will be listed here.

Abstract

Sarcopenia is defined as the loss of muscle mass or function and has been associated with increased morbidity and mortality in a variety of diseased populations. Sarcopenia results from a higher rate of muscle protein degradation compared to protein synthesis and is an important marker of metabolic status related to nutrition and physical activity. The diagnosis of sarcopenia is accomplished by clinical assessment demonstrating decreased muscle function and radiographic confirmation of decreased muscle mass, via dual X-ray absorptiometry, bioelectric impedance or cross-sectional imaging with CT or MRI. However, normative data for skeletal muscle mass are lacking, especially for children and young adults. Additionally, studies of skeletal muscle mass by cross-sectional imaging in children are scarce. Here, we review the concept of sarcopenia with an emphasis on its relevance in the pediatric population.

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References

Leong D, Teo K, Rangarajan S, Lopez-Jaramillo P, Avezum Jr A, Orlandini A . Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet. 2015; 386(9990):266-73. DOI: 10.1016/S0140-6736(14)62000-6. View

Nijholt W, Scafoglieri A, Jager-Wittenaar H, Hobbelen J, van der Schans C . The reliability and validity of ultrasound to quantify muscles in older adults: a systematic review. J Cachexia Sarcopenia Muscle. 2017; 8(5):702-712. PMC: 5659048. DOI: 10.1002/jcsm.12210. View

Seabolt L, Welch E, Silver H . Imaging methods for analyzing body composition in human obesity and cardiometabolic disease. Ann N Y Acad Sci. 2015; 1353:41-59. DOI: 10.1111/nyas.12842. View

Rossi A, Fantin F, Micciolo R, Bertocchi M, Bertassello P, Zanandrea V . Identifying sarcopenia in acute care setting patients. J Am Med Dir Assoc. 2014; 15(4):303.e7-12. DOI: 10.1016/j.jamda.2013.11.018. View

Antunes A, Araujo D, Verissimo M, Amaral T . Sarcopenia and hospitalisation costs in older adults: a cross-sectional study. Nutr Diet. 2017; 74(1):46-50. DOI: 10.1111/1747-0080.12287. View

Lee K, Shin Y, Huh J, Sung Y, Lee I, Yoon K . Recent Issues on Body Composition Imaging for Sarcopenia Evaluation. Korean J Radiol. 2019; 20(2):205-217. PMC: 6342757. DOI: 10.3348/kjr.2018.0479. View

Abiri B, Vafa M . Nutrition and sarcopenia: A review of the evidence of nutritional influences. Crit Rev Food Sci Nutr. 2017; 59(9):1456-1466. DOI: 10.1080/10408398.2017.1412940. View

Buckinx F, Landi F, Cesari M, Fielding R, Visser M, Engelke K . Pitfalls in the measurement of muscle mass: a need for a reference standard. J Cachexia Sarcopenia Muscle. 2018; 9(2):269-278. PMC: 5879987. DOI: 10.1002/jcsm.12268. View

Vellas B, Fielding R, Bens C, Bernabei R, Cawthon P, Cederholm T . Implications of ICD-10 for Sarcopenia Clinical Practice and Clinical Trials: Report by the International Conference on Frailty and Sarcopenia Research Task Force. J Frailty Aging. 2018; 7(1):2-9. DOI: 10.14283/jfa.2017.30. View

10.

Grimm A, Meyer H, Nickel M, Nittka M, Raithel E, Chaudry O . Evaluation of 2-point, 3-point, and 6-point Dixon magnetic resonance imaging with flexible echo timing for muscle fat quantification. Eur J Radiol. 2018; 103:57-64. DOI: 10.1016/j.ejrad.2018.04.011. View

11.

Gloor M, Fasler S, Fischmann A, Haas T, Bieri O, Heinimann K . Quantification of fat infiltration in oculopharyngeal muscular dystrophy: comparison of three MR imaging methods. J Magn Reson Imaging. 2010; 33(1):203-10. DOI: 10.1002/jmri.22431. View

12.

Prado C, Wells J, Smith S, Stephan B, Siervo M . Sarcopenic obesity: A Critical appraisal of the current evidence. Clin Nutr. 2012; 31(5):583-601. DOI: 10.1016/j.clnu.2012.06.010. View

13.

Belharbi S, Chatelain C, Herault R, Adam S, Thureau S, Chastan M . Spotting L3 slice in CT scans using deep convolutional network and transfer learning. Comput Biol Med. 2017; 87:95-103. DOI: 10.1016/j.compbiomed.2017.05.018. View

14.

Cruz-Jentoft A, Landi F, Schneider S, Zuniga C, Arai H, Boirie Y . Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age Ageing. 2014; 43(6):748-59. PMC: 4204661. DOI: 10.1093/ageing/afu115. View

15.

Chen L, Lee W, Peng L, Liu L, Arai H, Akishita M . Recent Advances in Sarcopenia Research in Asia: 2016 Update From the Asian Working Group for Sarcopenia. J Am Med Dir Assoc. 2016; 17(8):767.e1-7. DOI: 10.1016/j.jamda.2016.05.016. View

16.

Malmstrom T, Miller D, Simonsick E, Ferrucci L, Morley J . SARC-F: a symptom score to predict persons with sarcopenia at risk for poor functional outcomes. J Cachexia Sarcopenia Muscle. 2016; 7(1):28-36. PMC: 4799853. DOI: 10.1002/jcsm.12048. View

17.

Dedhia P, White Y, Dillman J, Adler J, Jarboe M, Teitelbaum D . Reduced paraspinous muscle area is associated with post-colectomy complications in children with ulcerative colitis. J Pediatr Surg. 2017; 53(3):477-482. DOI: 10.1016/j.jpedsurg.2017.09.006. View

18.

Derstine B, Holcombe S, Goulson R, Ross B, Wang N, Sullivan J . Quantifying Sarcopenia Reference Values Using Lumbar and Thoracic Muscle Areas in a Healthy Population. J Nutr Health Aging. 2018; 21(10):180-185. DOI: 10.1007/s12603-017-0983-3. View

19.

Bone A, Hepgul N, Kon S, Maddocks M . Sarcopenia and frailty in chronic respiratory disease. Chron Respir Dis. 2016; 14(1):85-99. PMC: 5720213. DOI: 10.1177/1479972316679664. View

20.

Mourtzakis M, Prado C, Lieffers J, Reiman T, McCargar L, Baracos V . A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab. 2008; 33(5):997-1006. DOI: 10.1139/H08-075. View