PIRCHE-II: an Algorithm to Predict Indirectly Recognizable HLA Epitopes in Solid Organ Transplantation

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 2019 Nov 20

PMID 31741009

Citations 30

Authors

Kirsten Geneugelijk

Eric Spierings

Affiliations

Soon will be listed here.

Abstract

Human leukocyte antigen (HLA) mismatches between donors and recipients may lead to alloreactivity after solid organ transplantation. Over the last few decades, our knowledge of the complexity of the HLA system has dramatically increased, as numerous new HLA alleles have been identified. As a result, the likelihood of alloreactive responses towards HLA mismatches after solid organ transplantation cannot easily be assessed. Algorithms are promising solutions to estimate the risk for alloreactivity after solid organ transplantation. In this review, we show that the recently developed PIRCHE-II (Predicted Indirectly ReCognizable HLA Epitopes) algorithm can be used to minimize alloreactivity towards HLA mismatches. Together with the use of other algorithms and simulation approaches, the PIRCHE-II algorithm aims for a better estimated alloreactive risk for individual patients and eventually an improved graft survival after solid organ transplantation.

Citing Articles

Editorial: Novel applications of epitope biology to improve outcomes in transplantation.

Lan J, Liwski R, Lima A, Tafulo S Front Genet. 2025; 16:1572987.

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Understanding HLA-DQ in renal transplantation: a mini-review.

Das R, Greenspan N Front Immunol. 2025; 16:1525306.

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Predicted indirectly recognizable HLA epitopes scores and clinical outcomes after haploidentical stem cell transplantation in pediatric patients with relapsed neuroblastoma.

Seo E, Jeong I, Ju H, Hyun J, Lee J, Yoo K Front Immunol. 2025; 16:1517387.

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Predicted Indirectly Recognizable T-cell Epitope (PIRCHE) Load Correlates With Rejection Events After Simultaneous Pancreas-Kidney Transplantation.

Parajuli S, Niemann M, Dale B, Hidalgo L, Gupta G, Kaufman D Transplant Direct. 2025; 11(3):e1764.

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