Error-Related Dynamics of Reaction Time and Frontal Midline Theta Activity in Attention Deficit Hyperactivity Disorder (ADHD) During a Subliminal Motor Priming Task

Overview

Journal Front Hum Neurosci

Specialty Neurology

Date 2019 Nov 19

PMID 31736729

Citations 3

Authors

Marius Keute

Max-Philipp Stenner

Marie-Kristin Mueller

Tino Zaehle

Kerstin Krauel

Affiliations

Soon will be listed here.

Abstract

Post-error slowing (PES) is an established performance monitoring readout. Several previous studies have found that PES is reduced in children and adolescents with attention-deficit hyperactivity disorder (ADHD). We analyzed reaction time data, along with electroencephalography (EEG) data, from a response priming experiment in children and adolescents with ADHD ( = 28) and typically developing (TD) controls ( = 15) between 10 and 17 years of age. We report dynamic reaction time changes before and after errors: whereas TD controls readjusted their response speed to their individual average speed after committing an error, this reaction time adjustment appeared to be delayed and decreased in ADHD patients. In the EEG, error trials were accompanied by increased frontal midline theta activity, which was attenuated in ADHD compared to TD. We conclude that PES has a different time course rather than being fully absent in ADHD and discuss relationships with our EEG findings and potential implications for performance monitoring in ADHD.

Citing Articles

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References

Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P . Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997; 36(7):980-8. DOI: 10.1097/00004583-199707000-00021. View

Genro J, Kieling C, Rohde L, Hutz M . Attention-deficit/hyperactivity disorder and the dopaminergic hypotheses. Expert Rev Neurother. 2010; 10(4):587-601. DOI: 10.1586/ern.10.17. View

van Meel C, Heslenfeld D, Oosterlaan J, Sergeant J . Adaptive control deficits in attention-deficit/hyperactivity disorder (ADHD): the role of error processing. Psychiatry Res. 2007; 151(3):211-20. DOI: 10.1016/j.psychres.2006.05.011. View

Ruthruff E . A test of the deadline model for speed-accuracy tradeoffs. Percept Psychophys. 1996; 58(1):56-64. DOI: 10.3758/bf03205475. View

Scheffers M, Coles M . Performance monitoring in a confusing world: error-related brain activity, judgments of response accuracy, and types of errors. J Exp Psychol Hum Percept Perform. 2000; 26(1):141-151. DOI: 10.1037//0096-1523.26.1.141. View

Keute M, Krauel K, Heinze H, Stenner M . Intact automatic motor inhibition in attention deficit hyperactivity disorder. Cortex. 2018; 109:215-225. DOI: 10.1016/j.cortex.2018.09.018. View

Mulder M, Bos D, Weusten J, Van Belle J, van Dijk S, Simen P . Basic impairments in regulating the speed-accuracy tradeoff predict symptoms of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2010; 68(12):1114-9. DOI: 10.1016/j.biopsych.2010.07.031. View

Asada H, Fukuda Y, Tsunoda S, Yamaguchi M, Tonoike M . Frontal midline theta rhythms reflect alternative activation of prefrontal cortex and anterior cingulate cortex in humans. Neurosci Lett. 1999; 274(1):29-32. DOI: 10.1016/s0304-3940(99)00679-5. View

Holroyd C, Umemoto A . The research domain criteria framework: The case for anterior cingulate cortex. Neurosci Biobehav Rev. 2016; 71:418-443. DOI: 10.1016/j.neubiorev.2016.09.021. View

10.

Groen Y, A Wijers A, Mulder L, Waggeveld B, Minderaa R, Althaus M . Error and feedback processing in children with ADHD and children with Autistic Spectrum Disorder: an EEG event-related potential study. Clin Neurophysiol. 2008; 119(11):2476-93. DOI: 10.1016/j.clinph.2008.08.004. View

11.

Cavanagh J, Shackman A . Frontal midline theta reflects anxiety and cognitive control: meta-analytic evidence. J Physiol Paris. 2014; 109(1-3):3-15. PMC: 4213310. DOI: 10.1016/j.jphysparis.2014.04.003. View

12.

Oostenveld R, Fries P, Maris E, Schoffelen J . FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. Comput Intell Neurosci. 2011; 2011:156869. PMC: 3021840. DOI: 10.1155/2011/156869. View

13.

McLoughlin G, Albrecht B, Banaschewski T, Rothenberger A, Brandeis D, Asherson P . Performance monitoring is altered in adult ADHD: a familial event-related potential investigation. Neuropsychologia. 2009; 47(14):3134-42. PMC: 3776647. DOI: 10.1016/j.neuropsychologia.2009.07.013. View

14.

Willcutt E, Doyle A, Nigg J, Faraone S, Pennington B . Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review. Biol Psychiatry. 2005; 57(11):1336-46. DOI: 10.1016/j.biopsych.2005.02.006. View

15.

Boudewyn M, Luck S, Farrens J, Kappenman E . How many trials does it take to get a significant ERP effect? It depends. Psychophysiology. 2017; 55(6):e13049. PMC: 5940511. DOI: 10.1111/psyp.13049. View

16.

Dudschig C, Jentzsch I . Speeding before and slowing after errors: is it all just strategy?. Brain Res. 2009; 1296:56-62. DOI: 10.1016/j.brainres.2009.08.009. View

17.

Danielmeier C, Ullsperger M . Post-error adjustments. Front Psychol. 2011; 2:233. PMC: 3173829. DOI: 10.3389/fpsyg.2011.00233. View

18.

Kofler M, Rapport M, Sarver D, Raiker J, Orban S, Friedman L . Reaction time variability in ADHD: a meta-analytic review of 319 studies. Clin Psychol Rev. 2013; 33(6):795-811. DOI: 10.1016/j.cpr.2013.06.001. View

19.

de Cheveigne A, Parra L . Joint decorrelation, a versatile tool for multichannel data analysis. Neuroimage. 2014; 98:487-505. DOI: 10.1016/j.neuroimage.2014.05.068. View

20.

Geburek A, Rist F, Gediga G, Stroux D, Pedersen A . Electrophysiological indices of error monitoring in juvenile and adult attention deficit hyperactivity disorder (ADHD)--a meta-analytic appraisal. Int J Psychophysiol. 2012; 87(3):349-62. DOI: 10.1016/j.ijpsycho.2012.08.006. View