Thuwalallenes A-E and Thuwalenynes A-C: New C Acetogenins with Anti-Inflammatory Activity from a Saudi Arabian Red Sea Sp

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2019 Nov 17

PMID 31731724

Citations 7

Authors

Aikaterini Koutsaviti

Maria G Daskalaki

Susana Agusti

Sotirios C Kampranis

Christos Tsatsanis

Carlos M Duarte

Vassilios Roussis

Efstathia Ioannou

Affiliations

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Abstract

Thuwalallenes A-E (-, and ) and thuwalenynes A-C (, , ), new C acetogenins featuring uncommon ring systems, along with -maneonene D (), thyrsiferol () and 23-acetyl-thyrsiferol () were isolated from the organic extract of a population of the red alga sp., collected at Rose Reef off the village of Thuwal in the Red Sea waters of the Kingdom of Saudi Arabia. The structure elucidation of the isolated natural products was based on extensive analysis of their spectroscopic data. Compounds -, , and were evaluated for their anti-inflammatory activity by quantifying nitric oxide (NO) release in response to TLR4 stimulation in macrophages. Besides compound that did not exhibit any activity, all other tested metabolites inhibited NO production from activated macrophages. Among them, thyrsiferol () and 23-acetylthyrsiferol () displayed activity with IC values in the low nM scale without cytotoxicity.

Citing Articles

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Alghrably M, Tammam M, Koutsaviti A, Roussis V, Lopez X, Bennici G Biomolecules. 2024; 14(8).

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Marine-Derived Leads as Anticancer Candidates by Disrupting Hypoxic Signaling through Hypoxia-Inducible Factors Inhibition.

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Naturally Occurring Organohalogen Compounds-A Comprehensive Review.

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New C Acetogenins from Two Species of from the Aegean Sea.

Harizani M, Diakaki D, Perdikaris S, Roussis V, Ioannou E Molecules. 2022; 27(6).

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New acetogenin katsuurallene from Laurencia saitoi collected from Katsuura, Japan.

Minamida Y, Matsuura H, Ishii T, Miyagi M, Shinjo Y, Sato K Nat Prod Bioprospect. 2022; 12(1):10.

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