Risk Factors and Outcomes of Preterm Premature Rupture of Membranes in a Cohort of 6968 Pregnant Women Prospectively Recruited

Overview

Journal J Clin Med

Specialty General Medicine

Date 2019 Nov 17

PMID 31731659

Citations 32

Authors

Damien Bouvier

Jean-Claude Forest

Loic Blanchon

Emmanuel Bujold

Bruno Pereira

Nathalie Bernard

Denis Gallot

Vincent Sapin

Yves Giguere

Affiliations

Soon will be listed here.

Abstract

We revisited risk factors and outcomes related to the preterm premature rupture of membranes (PPROM). A total of 7866 pregnant women were recruited during 5 years at their first prenatal visit to the perinatal clinic of the institution. We compared three groups (women without prematurity, women with spontaneous preterm labor with intact membranes (sPL with IM), women with PPROM) regarding 60 criteria about characteristics, lifestyle, medical, gynecological, obstetrical history of mothers, medication during pregnancy, events at delivery, and complications in neonates. Logistic regression analyses adjusting for potential confounding factors were used. Of the 6968 women selected, 189 (2.8%) presented a PPROM, and 225 (3.2%) an sPL with IM. The specific risk factors for PPROM were body mass index (BMI) <18.5 kg/m (adjusted odds ratio, aOR: 2.00 (1.09-3.67)), history of PPROM (aOR: 2.75 (1.19-6.36)), nulliparity (aOR: 2.52 (1.77-3.60)), gestational diabetes (aOR: 1.87 (1.16-2.99)), and low level of education (aOR: 2.39 (1.20-4.78)). The complications associated with PPROM were abruption placentae, cesarean, APGAR 5' <4, birth weight <2500 g, stillbirth, neonatal jaundice, and hospitalization of mother and neonates. All these complications were also associated with sPL with IM. Our study confirms some of the risk factors of PPROM and highlights a new one: gestational diabetes. Outcomes of PPROM are related to prematurity.

Citing Articles

Associations between maternal body composition in the second trimester and premature rupture of membranes: a retrospective study using hospital information system data.

Liao S, Xiong A, Xiong S, Zuo Y, Wang Y, Luo B BMC Pregnancy Childbirth. 2025; 25(1):241.

PMID: 40050777 PMC: 11883932. DOI: 10.1186/s12884-025-07334-4.

Day-to-day dynamics of fetal heart rate variability to detect chorioamnionitis in preterm premature rupture of membranes.

Taoum A, Carrault G, Tesson C, Esvan M, Laviolle B, Lassel L PLoS One. 2025; 20(1):e0305875.

PMID: 39746009 PMC: 11695014. DOI: 10.1371/journal.pone.0305875.

Influence of clinical risk factors for preterm premature rupture of membranes (PPROM) on the elastic strength of fetal membranes at term: A prospective study.

Robin A, Tessier Doyen N, Ben Rhaiem S, Valette N, Fermeaux V, Preux P PLoS One. 2024; 19(12):e0312760.

PMID: 39625959 PMC: 11614262. DOI: 10.1371/journal.pone.0312760.

The Immunomodulatory Role of Regulatory T Cells in Preterm Birth and Associated Pregnancy Outcomes.

Mureanu N, Bowman A, Porter-Wright I, Verma P, Efthymiou A, Nicolaides K Int J Mol Sci. 2024; 25(22).

PMID: 39595948 PMC: 11593591. DOI: 10.3390/ijms252211878.

Glycated albumin levels in the third trimester of women with gestational diabetes mellitus are associated with adverse pregnancy-related outcomes.

Pan Y, Gu R, Li Q, Wang J, Zhang Y, Zhao L BMC Pregnancy Childbirth. 2024; 24(1):774.

PMID: 39580395 PMC: 11585109. DOI: 10.1186/s12884-024-06994-y.

References

Peppa M, Vlassara H . Advanced glycation end products and diabetic complications: a general overview. Hormones (Athens). 2006; 4(1):28-37. DOI: 10.14310/horm.2002.11140. View

Sae-Lin P, Wanitpongpan P . Incidence and risk factors of preterm premature rupture of membranes in singleton pregnancies at Siriraj Hospital. J Obstet Gynaecol Res. 2018; 45(3):573-577. DOI: 10.1111/jog.13886. View

Ananth C, Oyelese Y, Srinivas N, Yeo L, Vintzileos A . Preterm premature rupture of membranes, intrauterine infection, and oligohydramnios: risk factors for placental abruption. Obstet Gynecol. 2004; 104(1):71-7. DOI: 10.1097/01.AOG.0000128172.71408.a0. View

Coppe J, Patil C, Rodier F, Sun Y, Munoz D, Goldstein J . Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008; 6(12):2853-68. PMC: 2592359. DOI: 10.1371/journal.pbio.0060301. View

Tchirikov M, Schlabritz-Loutsevitch N, Maher J, Buchmann J, Naberezhnev Y, Winarno A . Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome. J Perinat Med. 2017; 46(5):465-488. DOI: 10.1515/jpm-2017-0027. View

Berkowitz G, Blackmore-Prince C, Lapinski R, Savitz D . Risk factors for preterm birth subtypes. Epidemiology. 1998; 9(3):279-85. View

Williams K, Pastorek Ii J . Postpartum endomyometritis. Infect Dis Obstet Gynecol. 1995; 3(5):210-6. PMC: 2366154. DOI: 10.1155/S1064744995000640. View

Gosselink C, Ekwo E, Woolson R, Moawad A, Long C . Dietary habits, prepregnancy weight, and weight gain during pregnancy. Risk of pre term rupture of amniotic sac membranes. Acta Obstet Gynecol Scand. 1992; 71(6):425-38. DOI: 10.3109/00016349209021091. View

Goldenberg R, Culhane J, Iams J, Romero R . Epidemiology and causes of preterm birth. Lancet. 2008; 371(9606):75-84. PMC: 7134569. DOI: 10.1016/S0140-6736(08)60074-4. View

10.

Nabet C, Lelong N, Ancel P, Saurel-Cubizolles M, Kaminski M . Smoking during pregnancy according to obstetric complications and parity: results of the EUROPOP study. Eur J Epidemiol. 2007; 22(10):715-21. DOI: 10.1007/s10654-007-9172-8. View

11.

Shen T, DeFranco E, Stamilio D, Chang J, Muglia L . A population-based study of race-specific risk for preterm premature rupture of membranes. Am J Obstet Gynecol. 2008; 199(4):373.e1-7. DOI: 10.1016/j.ajog.2008.05.011. View

12.

NAEYE R, Peters E . Causes and consequences of premature rupture of fetal membranes. Lancet. 1980; 1(8161):192-4. DOI: 10.1016/s0140-6736(80)90674-1. View

13.

Menon R, Richardson L . Preterm prelabor rupture of the membranes: A disease of the fetal membranes. Semin Perinatol. 2017; 41(7):409-419. PMC: 5659934. DOI: 10.1053/j.semperi.2017.07.012. View

14.

Spinillo A, Nicola S, Piazzi G, Ghazal K, Colonna L, Baltaro F . Epidemiological correlates of preterm premature rupture of membranes. Int J Gynaecol Obstet. 1994; 47(1):7-15. DOI: 10.1016/0020-7292(94)90454-5. View

15.

Agarwal M . Gestational diabetes mellitus: An update on the current international diagnostic criteria. World J Diabetes. 2015; 6(6):782-91. PMC: 4478575. DOI: 10.4239/wjd.v6.i6.782. View

16.

Jelliffe-Pawlowski L, Baer R, Blumenfeld Y, Ryckman K, OBrodovich H, Gould J . Maternal characteristics and mid-pregnancy serum biomarkers as risk factors for subtypes of preterm birth. BJOG. 2015; 122(11):1484-93. PMC: 4704442. DOI: 10.1111/1471-0528.13495. View

17.

Dekker G, Lee S, North R, McCowan L, Simpson N, Roberts C . Risk factors for preterm birth in an international prospective cohort of nulliparous women. PLoS One. 2012; 7(7):e39154. PMC: 3398037. DOI: 10.1371/journal.pone.0039154. View

18.

Marret H, Descamps P, Fignon A, Perrotin F, Body G, Lansac J . [Management of premature rupture of membranes in a monofetal pregnancy before 28 weeks gestation]. J Gynecol Obstet Biol Reprod (Paris). 1999; 27(7):665-75. View

19.

Shree R, Caughey A, Chandrasekaran S . Short interpregnancy interval increases the risk of preterm premature rupture of membranes and early delivery. J Matern Fetal Neonatal Med. 2017; 31(22):3014-3020. PMC: 5984161. DOI: 10.1080/14767058.2017.1362384. View

20.

Kuba K, Bernstein P . ACOG Practice Bulletin No. 188: Prelabor Rupture of Membranes. Obstet Gynecol. 2018; 131(6):1163-1164. DOI: 10.1097/AOG.0000000000002663. View