SOX6 Suppresses the Development of Lung Adenocarcinoma by Regulating Expression of P53, P21 , Cyclin D1 and β-catenin

Overview

Journal FEBS Open Bio

Specialty Biology

Date 2019 Nov 16

PMID 31729835

Citations 9

Authors

Liyan Lv

Min Zhou

Jian Zhang

Fang Liu

Li Qi

Shuai Zhang

Yi Bi

Yan Yu

Affiliations

Soon will be listed here.

Abstract

The Sry-related high-mobility group box6 (SOX6) has been implicated in the development of cancer, but its role in lung cancer is incompletely understood. Here, we report that SOX6 expression is frequently down-regulated in lung adenocarcinoma tissues. Moreover, SOX6 can inhibit the proliferation and invasion of lung adenocarcinoma cells, which may occur through cell cycle arrest at G1/S due to up-regulation of p53 and p21 and down-regulation of cyclin D1 and β-catenin. Univariate and multivariate analyses revealed that the expression of SOX6 is significantly associated with patient disease-related survival and is an independent prognostic factor for lung adenocarcinoma. These data suggest that SOX6 may act as a suppressor of lung adenocarcinoma.

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