Update of Inflammasome Activation in Microglia/macrophage in Aging and Aging-related Disease

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2019 Nov 16

PMID 31729181

Citations 32

Authors

Meng-Yan Hu

Yin-Yao Lin

Bing-Jun Zhang

Dan-Li Lu

Zheng-Qi Lu

Wei Cai

Affiliations

Soon will be listed here.

Abstract

Aging and aging-related CNS diseases are associated with inflammatory status. As an efficient amplifier of immune responses, inflammasome is activated and played detrimental role in aging and aging-related CNS diseases. Macrophage and microglia display robust inflammasome activation in infectious and sterile inflammation. This review discussed the impact of inflammasome activation in microglia/macrophage on senescence "inflammaging" and aging-related CNS diseases. The preventive or therapeutic effects of targeting inflammasome on retarding aging process or tackling aging-related diseases are also discussed.

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