Stem Cells in Pituitary Tumors: Experimental Evidence Supporting Their Existence and Their Role in Tumor Clinical Behavior

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2019 Nov 12

PMID 31708878

Citations 5

Authors

Giovanna Mantovani

Elena Giardino

Donatella Treppiedi

Rosa Catalano

Federica Mangili

Anna Spada

Maura Arosio

Erika Peverelli

Affiliations

Soon will be listed here.

Abstract

Although generally benign, pituitary tumors frequently show local invasiveness and resistance to pharmacological therapy. After the demonstration of the existence of pituitary gland stem cells, over the past decade, the presence of a stem cell subpopulation in pituitary tumors has been investigated, analogous to the cancer stem cell model developed for malignant tumors. This review recapitulates the experimental evidence supporting the existence of a population of stem-like cells in pituitary tumors, focusing on their potential role in tumor initiation, progression, recurrence and resistance to pharmacological therapy.

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References

Greenman Y, Cooper O, Yaish I, Robenshtok E, Sagiv N, Jonas-Kimchi T . Treatment of clinically nonfunctioning pituitary adenomas with dopamine agonists. Eur J Endocrinol. 2016; 175(1):63-72. DOI: 10.1530/EJE-16-0206. View

Wurth R, Barbieri F, Pattarozzi A, Gaudenzi G, Gatto F, Fiaschi P . Phenotypical and Pharmacological Characterization of Stem-Like Cells in Human Pituitary Adenomas. Mol Neurobiol. 2016; 54(7):4879-4895. DOI: 10.1007/s12035-016-0025-x. View

Tirosh A, Shimon I . Management of macroprolactinomas. Clin Diabetes Endocrinol. 2017; 1:5. PMC: 5469196. DOI: 10.1186/s40842-015-0006-4. View

Guelho D, Grossman A . Emerging drugs for Cushing's disease. Expert Opin Emerg Drugs. 2015; 20(3):463-78. DOI: 10.1517/14728214.2015.1047762. View

Quintana E, Shackleton M, Sabel M, Fullen D, Johnson T, Morrison S . Efficient tumour formation by single human melanoma cells. Nature. 2008; 456(7222):593-8. PMC: 2597380. DOI: 10.1038/nature07567. View

Nowak D, Stewart D, Koeffler H . Differentiation therapy of leukemia: 3 decades of development. Blood. 2009; 113(16):3655-65. PMC: 2943835. DOI: 10.1182/blood-2009-01-198911. View

Marko N, Coughlan C, Weil R . Towards an integrated molecular and clinical strategy to predict early recurrence in surgically resected non-functional pituitary adenomas. J Clin Neurosci. 2012; 19(11):1535-40. DOI: 10.1016/j.jocn.2012.01.038. View

Mertens F, Gremeaux L, Chen J, Fu Q, Willems C, Roose H . Pituitary tumors contain a side population with tumor stem cell-associated characteristics. Endocr Relat Cancer. 2015; 22(4):481-504. DOI: 10.1530/ERC-14-0546. View

Mathioudakis N, Sundaresh R, Larsen A, Ruff W, Schiller J, Guerrero-Cazares H . Expression of the pituitary stem/progenitor marker GFRα2 in human pituitary adenomas and normal pituitary. Pituitary. 2014; 18(1):31-41. PMC: 4090297. DOI: 10.1007/s11102-014-0553-1. View

10.

Bahmad H, Mouhieddine T, Chalhoub R, Assi S, Araji T, Chamaa F . The Akt/mTOR pathway in cancer stem/progenitor cells is a potential therapeutic target for glioblastoma and neuroblastoma. Oncotarget. 2018; 9(71):33549-33561. PMC: 6173359. DOI: 10.18632/oncotarget.26088. View

11.

Prieto-Vila M, Takahashi R, Usuba W, Kohama I, Ochiya T . Drug Resistance Driven by Cancer Stem Cells and Their Niche. Int J Mol Sci. 2017; 18(12). PMC: 5751177. DOI: 10.3390/ijms18122574. View

12.

Chen J, Hersmus N, Van Duppen V, Caesens P, Denef C, Vankelecom H . The adult pituitary contains a cell population displaying stem/progenitor cell and early embryonic characteristics. Endocrinology. 2005; 146(9):3985-98. DOI: 10.1210/en.2005-0185. View

13.

Losa M, Mortini P, Barzaghi R, Ribotto P, Terreni M, Bianchi Marzoli S . Early results of surgery in patients with nonfunctioning pituitary adenoma and analysis of the risk of tumor recurrence. J Neurosurg. 2008; 108(3):525-32. DOI: 10.3171/JNS/2008/108/3/0525. View

14.

Goto N, Fukuda A, Yamaga Y, Yoshikawa T, Maruno T, Maekawa H . Lineage tracing and targeting of IL17RB tuft cell-like human colorectal cancer stem cells. Proc Natl Acad Sci U S A. 2019; 116(26):12996-13005. PMC: 6601016. DOI: 10.1073/pnas.1900251116. View

15.

Al-Hajj M, Wicha M, Benito-Hernandez A, Morrison S, Clarke M . Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A. 2003; 100(7):3983-8. PMC: 153034. DOI: 10.1073/pnas.0530291100. View

16.

Xu Q, Yuan X, Tunici P, Liu G, Fan X, Xu M . Isolation of tumour stem-like cells from benign tumours. Br J Cancer. 2009; 101(2):303-11. PMC: 2720199. DOI: 10.1038/sj.bjc.6605142. View

17.

Barker N, Ridgway R, van Es J, van de Wetering M, Begthel H, van den Born M . Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 2008; 457(7229):608-11. DOI: 10.1038/nature07602. View

18.

Medema J . Cancer stem cells: the challenges ahead. Nat Cell Biol. 2013; 15(4):338-44. DOI: 10.1038/ncb2717. View

19.

Batlle E, Clevers H . Cancer stem cells revisited. Nat Med. 2017; 23(10):1124-1134. DOI: 10.1038/nm.4409. View

20.

Martinez-Barbera J, Andoniadou C . Concise Review: Paracrine Role of Stem Cells in Pituitary Tumors: A Focus on Adamantinomatous Craniopharyngioma. Stem Cells. 2016; 34(2):268-76. PMC: 4864894. DOI: 10.1002/stem.2267. View