LVSI Positive and NX in Early Endometrial Cancer: Surgical Restaging (and No Further Treatment if N0), or Adjuvant ERT?

Overview

Journal Gynecol Oncol

Date 2019 Nov 10

PMID 31703813

Citations 11

Authors

Katherine L Harris

Kathryn A Maurer

Elke Jarboe

Theresa L Werner

David Gaffney

Affiliations

Soon will be listed here.

Abstract

Early endometrial cancer has an overall survival of greater than 80% (1). One of the poor prognostic factors that may be associated with the 20% who do not survive 5 years is the presence of lymphovascular space invasion (LVSI). LVSI is associated with increased nodal metastasis and decreased progression free survival (PFS) and overall survival (OS). (2-8). Therefore, unstaged, LVSI positive early endometrial cancer requires additional management with either completion of staging with lymphadenectomy or adjuvant radiation. We focus on reviewing the management of natural history and management of early endometrial cancer followed by the prognostic impact of LVSI, management options and recommendations.

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