Impact of the Total Number of Carotid Plaques on the Outcome of Ischemic Stroke Patients with Atrial Fibrillation

Overview

Journal J Clin Med

Specialty General Medicine

Date 2019 Nov 10

PMID 31703280

Citations 3

Authors

Hyungjong Park

Minho Han

Young Dae Kim

Joonsang Yoo

Hye Sun Lee

Jin Kyo Choi

Ji Hoe Heo

Hyo Suk Nam

Affiliations

Soon will be listed here.

Abstract

Background: Atrial fibrillation (AF) shares several risk factors with atherosclerosis. We investigated the association between total carotid plaque number (TPN) and long-term prognosis in ischemic stroke patients with AF.

Methods: A total of 392 ischemic stroke patients with AF who underwent carotid ultrasonography were enrolled. TPN was assessed using B-mode ultrasound. The patients were categorized into two groups according to best cutoff values for TPN (TPN ≤ 4 vs. TPN ≥ 5). The long-term risk of major adverse cardiovascular events (MACE) and mortality according to TPN was investigated using a Cox hazard model.

Results: After a mean follow-up of 2.42 years, 113 patients (28.8%) had developed MACE and 88 patients (22.4%) had died. MACE occurred more frequently in the TPN ≥ 5 group than in the TPN ≤ 4 group (adjusted hazard ratio [HR], 1.50; 95% confidence interval [CI], 1.01-2.21; < 0.05). Moreover, the TPN ≥ 5 group showed an increased risk of all-cause mortality (adjusted HR, 2.69; 95% CI, 1.40-5.17; < 0.05). TPN along with maximal plaque thickness and intima media thickness showed improved prognostic utility when added to the variables of the CHADDS-VASc score.

Conclusion: TPN can predict the long-term outcome of ischemic stroke patients with AF. Adding TPN to the CHADDS-VASc score increases the predictability of outcome after stroke.

Citing Articles

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