Tc-99m Hydroxymethylene Diphosphonate SPECT/CT for the Evaluation of Osteonecrosis of the Jaw: Preliminary Study on Diagnostic Ability of Maximum Standardised Uptake Value

Overview

Journal Clin Radiol

Specialty Radiology

Date 2019 Nov 9

PMID 31699430

Citations 14

Authors

I Ogura

Y Sasaki

M Sue

T Oda

A Kameta

K Hayama

Affiliations

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Abstract

Aim: To investigate the diagnostic ability of maximum standardised uptake value (SUV) at combined single-photon-emission computed tomography/computed tomography (SPECT/CT) for the evaluation of osteonecrosis of the jaw.

Materials And Methods: Seven patients with mandibular osteonecrosis (three osteoradionecrosis, three medication-related osteonecrosis of the jaw (MRONJ), and one rheumatoid arthritis) underwent SPECT/CT at 4 hours after injection of technetium 99m hydroxymethylene diphosphonate. The SPECT/CT parameters SUV were compared for the osteonecrosis with normal mandible. Statistical analyses among the SUV of osteonecrosis were performed by one-way repeated measures analysis of variance with Tukey's HSD (honestly significant difference) test. A p-value <0.05 was considered statistically significant.

Results: SUV for MRONJ and rheumatoid arthritis (23.24±8.63) were significantly higher than those for osteoradionecrosis (9.05±1.39, p=0.005) and normal mandible (3.57±0.46, p=0.000).

Conclusions: SUV derived from bone SPECT/CT could be useful for the evaluation of osteonecrosis of the jaw.

Citing Articles

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Analysis of bone single-photon emission CT/CT and diffusion-weighted MR imaging in medication-related osteonecrosis of the jaw: focusing on the correlation between standardized uptake values and apparent diffusion coefficient values.

Tezuka Y, Ogura I Am J Nucl Med Mol Imaging. 2024; 14(4):230-238.

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Histopathological findings affect quantitative values of single photon emission computed tomography in patients with antiresorptive agent-related osteonecrosis of the jaws.

Okui T, Kobayashi Y, Isomura M, Tsujimoto M, Satoh K, Toyama H Fujita Med J. 2023; 9(3):186-193.

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Maximum and mean standardized uptake values of medication-related osteonecrosis of the jaw with bone SPECT/CT: comparison of mandibular pathologies, control and temporomandibular joints.

Tezuka Y, Ogura I Dentomaxillofac Radiol. 2023; 52(6):20230119.

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