Does the Nitrogen Single-breath Washout Test Contribute to Detecting Pulmonary Involvement in Rheumatoid Arthritis? A Pilot Study

Overview

Journal BMC Res Notes

Publisher Biomed Central

Specialties Biology
General Medicine

Date 2019 Nov 9

PMID 31699130

Citations 3

Authors

Elizabeth Jauhar Cardoso Bessa

Felipe de Miranda Carbonieri Ribeiro

Geraldo da Rocha Castelar Pinheiro

Agnaldo Jose Lopes

Affiliations

Soon will be listed here.

Abstract

Objective: There has been growing interest in studying small airway disease through measures of ventilation distribution, thanks to the resurgence of the nitrogen single-breath washout (NSBW) test. Therefore, this study evaluated the contribution of the NSBW test to the detection of pulmonary involvement in patients with rheumatoid arthritis (RA).

Results: Twenty-one patients with RA underwent clinical evaluation, pulmonary function tests (PFTs), including the N2BW test, and computed tomography (CT). The main tomographic findings were air trapping and bronchiectasis (57.1% and 23.8% of cases, respectively). According to the phase III slope of the NSBW (phase III slope), 11 and 10 patients had values < 120% predicted and > 120% predicted, respectively. Five patients with limited involvement on CT had a phase III slope > 120%. The residual volume/total lung capacity ratio was significantly different between patients with phase III slopes < 120% and > 120% (P = 0.024). Additionally, rheumatoid factor positivity was higher in patients with a phase III slope > 120% (P = 0.021). In patients with RA and airway disease on CT, the NSBW test detects inhomogeneity in the ventilation distribution in approximately half of the cases, even in those with normal conventional PFT results.

Citing Articles

Association between clinical, serological, functional and radiological findings and ventilatory distribution heterogeneity in patients with rheumatoid arthritis.

Bessa E, Ribeiro F, Rodrigues R, Costa C, Rufino R, da Rocha Castelar Pinheiro G PLoS One. 2023; 18(10):e0291659.

PMID: 37862308 PMC: 10588833. DOI: 10.1371/journal.pone.0291659.

Prevalence and risk factors of bronchiectasis in rheumatoid arthritis: A systematic review and meta-analysis.

Martin L, Prisco L, Huang W, McDermott G, Shadick N, Doyle T Semin Arthritis Rheum. 2021; 51(5):1067-1080.

PMID: 34450505 PMC: 8453125. DOI: 10.1016/j.semarthrit.2021.08.005.

Predictors of functional capacity as measured by the Glittre activities of daily living test in women with rheumatoid arthritis.

Palugan M, Assis A, Bessa E, Ferreira A, Lopes A Braz J Med Biol Res. 2021; 54(5):e10040.

PMID: 33729387 PMC: 7959171. DOI: 10.1590/1414-431X202010040.

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