Correlation Between Visual Acuity and Human Leukocyte Antigen DRB1*04 in Patients with Vogt-Koyanagi-Harada Disease

Overview

Journal BMC Ophthalmol

Publisher Biomed Central

Specialty Ophthalmology

Date 2019 Nov 9

PMID 31699055

Citations 1

Authors

Norihiko Misawa

Mizuki Tagami

Takeya Kohno

Shigeru Honda

Affiliations

Soon will be listed here.

Abstract

Background: The common presence of human leukocyte antigen (HLA)-DRB1*04 in Vogt-Koyanagi-Harada (VKH) disease is well known. The aim of this study was to investigate the relationship between visual prognosis and HLA-DRB1*04 alleles during systemic corticosteroid therapy in patients with VKH disease.

Methods: This retrospective case series included 57 eyes from 29 consecutive patients with treatment-naïve VKH disease who received systemic corticosteroid therapy. Visual acuity, sex, refractive error, central retinal thickness (CRT), central choroidal thickness (CCT), and duration from onset to treatment were measured at initial and final visits. Mean values of parameters were compared with each visit. Genotyping was performed by polymerase chain reaction amplification with sequence-specific primer.

Results: Linear regression showed significant differences in logMAR best-corrected visual acuity between the three groups of homozygotes, heterozygotes, and normal subjects at baseline (p < 0.01), at 3 months after treatment (p < 0.01). There was no significant differences at 6 months after treatment (p = 0.257). No significant differences were detected between the three groups in age, sex, refractive error, CRT, CCT, or duration from onset to treatment.

Conclusion: Alleles of HLA-DRB1*04 might affect visual prognosis and be related to early response after initiation of treatment in VKH disease.

Citing Articles

Early Changes in Ocular Biomarkers in Patients with Vogt-Koyanagi-Harada Disease after Pulse Steroid Therapy.

Muto T, Kawaguchi S, Kusuda S, Misu K, Sakamoto M, Machida S Ophthalmologica. 2024; 248(1):40-53.

PMID: 39571547 PMC: 11901411. DOI: 10.1159/000542724.

Visual outcomes and choroidal thickness associated with human leukocyte antigen DRB1*04 in unclassifiable uveitis in Japanese patients.

Misawa N, Tagami M, Sakai A, Kohno T, Honda S BMC Ophthalmol. 2021; 21(1):457.

PMID: 34963463 PMC: 8715637. DOI: 10.1186/s12886-021-02222-9.

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