Layer by Layer Antimicrobial Coatings Based on Nafion, Lysozyme, and Chitosan

Overview

Journal Nanomaterials (Basel)

Date 2019 Nov 7

PMID 31689966

Citations 8

Authors

Ella N Gibbons

Charis Winder

Elliot Barron

Diogo Fernandes

Marta J Krysmann

Antonios Kelarakis

Adam V S Parry

Stephen G Yeates

Affiliations

Soon will be listed here.

Abstract

The study focuses on the development of a new family of layer-by-layer coatings comprising Nafion, lysozyme and chitosan to address challenges related to microbial contamination. Circular dichroism was employed to gain insights on the interactions of the building blocks at the molecular level. Quartz crystal microbalance tests were used to monitor in real time the build-up of multilayer coatings, while atomic force microscopy, contact angle and surface zeta potential measurements were performed to assess the surface characteristics of the multilayer assemblies. Remarkably, the nanocoated surfaces show almost 100% reduction in the population of both and . The study suggests that Nafion based synergistic platforms can offer an effective line of defence against bacteria, facilitating antimicrobial mechanisms that go beyond the concept of exclusion zone.

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