A Systematic Genotype and Subgenotype Re-ranking of Hepatitis Under a Novel Classification Standard

Overview

Journal Heliyon

Specialty Social Sciences

Date 2019 Nov 6

PMID 31687483

Citations 9

Authors

Yonghua Yin

Kai He

Bingting Wu

Min Xu

Lianming Du

Wei Liu

Pu Liao

Yu Liu

Miao He

Affiliations

Soon will be listed here.

Abstract

Background And Aim: It is commonly noticed that chaotic and inefficient subgenotyping are universally used academically and clinically, a standardized HBV genotype/subgenotype classification criterion is urgently acquired. Sequence similarity, which was commonly used for the last three decades, should be upgraded by phylogenetic analysis in genotyping of recombinant-free HBV strains.

Methods: In this study, 4,429 HBV whole-genome sequences were employed to reconstruct the phylogeny of HBV using Bayesian inference. After excluding recombinant sequences, calculating partitioned evolutionary models, excluding recombinant sequences, reconstructing phylogenetic trees, and performing a correlation analysis of genetic distances, geographical distribution and serotypes, we systematically redefined the genotypes and subgenotypes of HBV.

Results: Compared to previous taxonomy, fourteen subgenotypes (A5-A7; B5-B9; C2-C4, C7; and D6-D7) were revised in the new standard. Now the HBV is divided into ten genotypes (A-J) and 24 subgenotypes (A1-A3; B1-B5; C1-C6; D1-D6; and F1-F4).

Conclusion: Our robust genotype/subgenotype new taxonomy has objectively re-molded the current shape of HBV classification. We believe that all future hepatitis B related researches or diagnosis will be benefited under the new HBV genotyping/subgenotyping standards.

Citing Articles

Hepatitis B Virus Genotypes and Subgenotypes Circulating in Infected Residents in a Country with High Vaccination Rate.

Silva C, Ramos D, Quina M, Padua E Viruses. 2024; 16(6).

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Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics.

SantAnna T, Araujo N Microorganisms. 2023; 11(5).

PMID: 37317074 PMC: 10221421. DOI: 10.3390/microorganisms11051101.

Locked nucleic acid real-time polymerase chain reaction method identifying two polymorphisms of hepatitis B virus genotype C2 infections, rt269L and rt269I.

Kim K, Choi Y, Kim D, Jang J, Choe W, Kim B World J Gastroenterol. 2023; 29(11):1721-1734.

PMID: 37077521 PMC: 10107212. DOI: 10.3748/wjg.v29.i11.1721.

Global prevalence and molecular characteristics of three clades within hepatitis B virus subgenotype C2: Predominance of the C2(3) clade in South Korea.

Kim D, Choi Y, Jang J, Kim B Front Microbiol. 2023; 14:1137084.

PMID: 36970691 PMC: 10033913. DOI: 10.3389/fmicb.2023.1137084.

Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide.

Marcelino R, Ezeonwumelu I, Janeiro A, Mimoso P, Matos S, Briz V PLoS One. 2022; 17(12):e0276618.

PMID: 36548381 PMC: 9778982. DOI: 10.1371/journal.pone.0276618.

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