Impact of Arterial Hypertension and Type 2 Diabetes on Cardiac Autonomic Modulation in Obese Individuals with Recommendation for Bariatric Surgery

Overview

Journal Diabetes Metab Syndr Obes

Publisher Dove Medical Press

Specialty Endocrinology

Date 2019 Nov 6

PMID 31686874

Citations 6

Authors

Nara Nobrega Crispim Carvalho

Francisco Antonio de Oliveira Junior

Gitana da Silva

Vinicius Jose Baccin Martins

Valdir de Andrade Braga

Joao Henrique da Costa-Silva

Flavia Cristina Fernandes Pimenta

Jose Luiz de Brito Alves

Affiliations

Soon will be listed here.

Abstract

Background And Aim: Obese individuals with recommendation for bariatric surgery (BS) exhibit increased cardiovascular risk. The association of obesity with comorbidities, such as arterial hypertension (HTN) and type 2 diabetes mellitus (T2DM) can worsen cardiovascular dysfunction. This study aimed to investigate the effect of HTN on cardiac autonomic function and whether diabetes exacerbates HTN-related impairment of autonomic function in obese subjects.

Methods: Samples (n=63) were allocated to three groups: Obese without HTN and T2DM (n=29), Obese with HTN (OHTN, n=17) and OHTN with T2DM (OHTN+T2DM, n=17), in which anthropometric measures, body composition, blood biochemical parameters, blood pressure (BP) and heart rate variability (HRV) were evaluated.

Results: The age was higher in OHTN+T2DM and OHTN than in obese groups (<0.05). OHTN+T2DM individuals had increased neck circumference and compromised glycemic profile when compared to obese and OHTN groups (<0.05). Mean values for standard deviation of RR (SDRR), square root of the mean squared differences of successive RR interval (RMSSD) and number of pairs of successive normal-to-normal beat intervals that differed by 50 ms (pRR50) were significantly lower in OHTN+T2DM and OHTN groups when compared to patients with obesity alone (<0.05). The low frequency (LF), low frequency/high frequency (LF/HF) ratio were higher in the OHTN+T2DM and OHTN than subjects with obesity alone (<0.05). Nonlinear parameters SD2 and SD1 were also lower in the OHTN+T2DM when compared to the obese group (<0.05). However, the SD2/SD1 ratio was higher in the OHTN+T2DM and OHTN groups than the obese group.

Conclusion: T2DM and/or HTN impair the cardiac autonomic function in obese patients. However, the presence of T2DM did not exacerbate the hypertension-related impairment of autonomic function.

Citing Articles

Analysis of heart rate as a predictor of changes in heart rate variability in children.

Costa P, Neta A, Baccin Martins V, Alves J Rev Paul Pediatr. 2024; 43:e2024045.

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Effects of preoperative sarcopenia-related parameters on the musculoskeletal and metabolic outcomes after bariatric surgery: a one-year longitudinal study in females.

Crispim Carvalho N, Baccin Martins V, Filho J, Neta A, Pimenta F, Alves J Sci Rep. 2023; 13(1):13373.

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Effects of Preoperative Sarcopenia-Related Parameters on Cardiac Autonomic Function in Women with Obesity Following Bariatric Surgery: A One-Year Prospective Study.

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Association of worsening of nonalcoholic fatty liver disease with cardiometabolic function and intestinal bacterial overgrowth: A cross-sectional study.

Lira M, de Medeiros Filho J, Baccin Martins V, da Silva G, de Oliveira Junior F, de Almeida Filho E PLoS One. 2020; 15(8):e0237360.

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