Obesity Affects β2 Adrenergic Regulation of the Inflammatory Profile and Phenotype of Circulating Monocytes from Exercised Animals

Overview

Journal Nutrients

Date 2019 Nov 6

PMID 31684076

Citations 6

Authors

Isabel Galvez

Leticia Martin-Cordero

Maria Dolores Hinchado

Alberto Alvarez-Barrientos

Eduardo Ortega

Affiliations

Soon will be listed here.

Abstract

Anomalous immune/inflammatory responses in obesity take place along with alterations in the neuroendocrine responses and dysregulation in the immune/stress feedback mechanisms. Exercise is a potential anti-inflammatory strategy in this context, but the influence of exercise on the β2 adrenergic regulation of the monocyte-mediated inflammatory response in obesity remains completely unknown. The first objective of this study was to analyze the effect of exercise on the inflammatory profile and phenotype of monocytes from obese and lean animals, and the second aim was to determine whether obesity could affect monocytes' inflammatory response to β2 adrenergic activation in exercised animals. C57BL/6J mice were allocated to different lean or obese groups: sedentary, with acute exercise, or with regular exercise. The inflammatory profile and phenotype of their circulating monocytes were evaluated by flow cytometry in the presence or absence of the selective β2 adrenergic receptor agonist terbutaline. Exercise caused an anti-inflammatory effect in obese individuals and a pro-inflammatory effect in lean individuals. β2 adrenergic receptor stimulation exerted a global pro-inflammatory effect in monocytes from exercised obese animals and an anti-inflammatory effect in monocytes from exercised lean animals. Thus, β2 adrenergic regulation of inflammation in monocytes from exercised animals seems to depend on the inflammatory basal set-point.

Citing Articles

The Influence of Obesity and Weight Loss on the Bioregulation of Innate/Inflammatory Responses: Macrophages and Immunometabolism.

Galvez I, Navarro M, Martin-Cordero L, Otero E, Hinchado M, Ortega E Nutrients. 2022; 14(3).

PMID: 35276970 PMC: 8840693. DOI: 10.3390/nu14030612.

Effects of β-Blockers on the Sympathetic and Cytokines Storms in Covid-19.

Al-Kuraishy H, Al-Gareeb A, Mostafa-Hedeab G, Kasozi K, Zirintunda G, Aslam A Front Immunol. 2021; 12:749291.

PMID: 34867978 PMC: 8637815. DOI: 10.3389/fimmu.2021.749291.

Influence of Obesity and Exercise on β2-Adrenergic-Mediated Anti-Inflammatory Effects in Peritoneal Murine Macrophages.

Martin-Cordero L, Galvez I, Hinchado M, Ortega E Biomedicines. 2020; 8(12).

PMID: 33266248 PMC: 7761150. DOI: 10.3390/biomedicines8120556.

β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise.

Galvez I, Martin-Cordero L, Hinchado M, Ortega E Nutrients. 2020; 12(5).

PMID: 32429330 PMC: 7284544. DOI: 10.3390/nu12051438.

Crescent-Like Lesions as an Early Signature of Nephropathy in a Rat Model of Prediabetes Induced by a Hypercaloric Diet.

Nunes S, Alves A, Preguica I, Barbosa A, Vieira P, Mendes F Nutrients. 2020; 12(4).

PMID: 32218109 PMC: 7230605. DOI: 10.3390/nu12040881.

References

Ratge D, Wiedemann A, Kohse K, WISSER H . Alterations of beta-adrenoceptors on human leukocyte subsets induced by dynamic exercise: effect of prednisone. Clin Exp Pharmacol Physiol. 1988; 15(1):43-53. DOI: 10.1111/j.1440-1681.1988.tb01007.x. View

Garcia J, Saez M, De la Fuente M, Ortega E . Regulation of phagocytic process of macrophages by noradrenaline and its end metabolite 4-hydroxy-3-metoxyphenyl-glycol. Role of alpha- and beta-adrenoreceptors. Mol Cell Biochem. 2003; 254(1-2):299-304. DOI: 10.1023/a:1027345820519. View

Hotamisligil G . Inflammation and metabolic disorders. Nature. 2006; 444(7121):860-7. DOI: 10.1038/nature05485. View

Rincon E . Physiology and biochemistry: influence of exercise on phagocytosis. Int J Sports Med. 1994; 15 Suppl 3:S172-8. DOI: 10.1055/s-2007-1021133. View

Galvez I, Martin-Cordero L, Hinchado M, Alvarez-Barrientos A, Ortega E . Anti-inflammatory effect of β2 adrenergic stimulation on circulating monocytes with a pro-inflammatory state in high-fat diet-induced obesity. Brain Behav Immun. 2019; 80:564-572. DOI: 10.1016/j.bbi.2019.04.042. View

Kohm A, Sanders V . Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo. Pharmacol Rev. 2001; 53(4):487-525. View

Ortega E, Giraldo E, Hinchado M, Martin L, Garcia J, De la Fuente M . Neuroimmunomodulation during exercise: role of catecholamines as 'stress mediator' and/or 'danger signal' for the innate immune response. Neuroimmunomodulation. 2007; 14(3-4):206-12. DOI: 10.1159/000110648. View

Reilly S, Saltiel A . Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol. 2017; 13(11):633-643. DOI: 10.1038/nrendo.2017.90. View

Nance D, Sanders V . Autonomic innervation and regulation of the immune system (1987-2007). Brain Behav Immun. 2007; 21(6):736-45. PMC: 1986730. DOI: 10.1016/j.bbi.2007.03.008. View

10.

De la Fuente M, Cruces J, Hernandez O, Ortega E . Strategies to improve the functions and redox state of the immune system in aged subjects. Curr Pharm Des. 2011; 17(36):3966-93. DOI: 10.2174/138161211798764861. View

11.

Dimitrov S, Hulteng E, Hong S . Inflammation and exercise: Inhibition of monocytic intracellular TNF production by acute exercise via β-adrenergic activation. Brain Behav Immun. 2016; 61:60-68. PMC: 6555138. DOI: 10.1016/j.bbi.2016.12.017. View

12.

Burman K, Ferguson E, Djuh Y, Wartofsky L, Latham K . Beta receptors in peripheral mononuclear cells increase acutely during exercise. Acta Endocrinol (Copenh). 1985; 109(4):563-8. DOI: 10.1530/acta.0.1090563. View

13.

Martin-Cordero L, Garcia J, Giraldo E, de la Fuente M, Manso R, Ortega E . Influence of exercise on the circulating levels and macrophage production of IL-1beta and IFNgamma affected by metabolic syndrome: an obese Zucker rat experimental animal model. Eur J Appl Physiol. 2009; 107(5):535-43. DOI: 10.1007/s00421-009-1140-4. View

14.

Ortega E, Galvez I, Martin-Cordero L . Adrenergic Regulation of Macrophage-Mediated Innate/Inflammatory Responses in Obesity and Exercise in this Condition: Role of β2 Adrenergic Receptors. Endocr Metab Immune Disord Drug Targets. 2019; 19(8):1089-1099. PMC: 7046986. DOI: 10.2174/1871530319666190206124520. View

15.

Ortega E, Garcia J, de la Fuente M . Modulation of adherence and chemotaxis of macrophages by norepinephrine. Influence of ageing. Mol Cell Biochem. 2000; 203(1-2):113-7. DOI: 10.1023/a:1007094614047. View

16.

Das U . Is metabolic syndrome X an inflammatory condition?. Exp Biol Med (Maywood). 2002; 227(11):989-97. DOI: 10.1177/153537020222701106. View

17.

Bellinger D, Lorton D . Autonomic regulation of cellular immune function. Auton Neurosci. 2014; 182:15-41. DOI: 10.1016/j.autneu.2014.01.006. View

18.

Mraz M, Haluzik M . The role of adipose tissue immune cells in obesity and low-grade inflammation. J Endocrinol. 2014; 222(3):R113-27. DOI: 10.1530/JOE-14-0283. View

19.

Ortega E . Neuroendocrine mediators in the modulation of phagocytosis by exercise: physiological implications. Exerc Immunol Rev. 2003; 9:70-93. View

20.

Bastard J, Maachi M, Lagathu C, Kim M, Caron M, Vidal H . Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006; 17(1):4-12. View