Rousettus Aegyptiacus Bats Do Not Support Productive Nipah Virus Replication

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2019 Nov 5

PMID 31682727

Citations 12

Authors

Stephanie N Seifert

Michael C Letko

Trenton Bushmaker

Eric D Laing

Greg Saturday

Kimberly Meade-White

Neeltje van Doremalen

Christopher C Broder

Vincent J Munster

Affiliations

Soon will be listed here.

Abstract

Nipah virus (NiV) is a bat-borne zoonotic pathogen that can cause severe respiratory distress and encephalitis upon spillover into humans. NiV is capable of infecting a broad range of hosts including humans, pigs, ferrets, dogs, cats, hamsters, and at least 2 genera of bats. Little is known about the biology of NiV in the bat reservoir. In this study, we evaluate the potential for the Egyptian fruit bat (EFB), Rousettus aegyptiacus, to serve as a model organism for studying NiV in bats. Our data suggest that NiV does not efficiently replicate in EFBs in vivo. Furthermore, we show no seroconversion against NiV glycoprotein and a lack of viral replication in primary and immortalized EFB-derived cell lines. Our data show that despite using a conserved target for viral entry, NiV replication is limited in some bat species. We conclude that EFBs are not an appropriate organism to model NiV infection or transmission in bats.

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