An Electrochemical Study on the Effect of Metal Chelation and Reactive Oxygen Species on a Synthetic Neuromelanin Model

Overview

Journal Front Bioeng Biotechnol

Date 2019 Nov 5

PMID 31681735

Citations 3

Authors

Ri Xu

Francesca Soavi

Clara Santato

Affiliations

Soon will be listed here.

Abstract

Neuromelanin is present in the cathecolaminergic neuron cells of the and of the midbrain of primates. Neuromelanin plays a role in Parkinson's disease (PD). Literature reports that neuromelanin features, among others, antioxidant properties by metal ion chelation and free radical scavenging. The pigment has been reported to have prooxidant properties too, in certain experimental conditions. We propose an explorative electrochemical study of the effect of the presence of metal ions and reactive oxygen species (ROS) on the cyclic voltammograms of a synthetic model of neuromelanin. Our work improves the current understanding on experimental conditions where neuromelanin plays an antioxidant or prooxidant behavior, thus possibly contributing to shed light on factors promoting the appearance of PD.

Citing Articles

A comparative characterization study between fungal and bacterial eumelanin pigments.

Bayram S Indian J Microbiol. 2022; 62(3):393-400.

PMID: 35974917 PMC: 9375792. DOI: 10.1007/s12088-022-01012-1.

Melanins as Sustainable Resources for Advanced Biotechnological Applications.

Galeb H, Wilkinson E, Stowell A, Lin H, Murphy S, Martin-Hirsch P Glob Chall. 2021; 5(2):2000102.

PMID: 33552556 PMC: 7857133. DOI: 10.1002/gch2.202000102.

The Neuromelanin Paradox and Its Dual Role in Oxidative Stress and Neurodegeneration.

Moreno-Garcia A, Kun A, Calero M, Calero O Antioxidants (Basel). 2021; 10(1).

PMID: 33467040 PMC: 7829956. DOI: 10.3390/antiox10010124.

References

Liu Y, Hong L, Kempf V, Wakamatsu K, Ito S, Simon J . Ion-exchange and adsorption of Fe(III) by Sepia melanin. Pigment Cell Res. 2004; 17(3):262-9. DOI: 10.1111/j.1600-0749.2004.00140.x. View

Kortleven C, Fasano C, Thibault D, Lacaille J, Trudeau L . The endocannabinoid 2-arachidonoylglycerol inhibits long-term potentiation of glutamatergic synapses onto ventral tegmental area dopamine neurons in mice. Eur J Neurosci. 2011; 33(10):1751-60. DOI: 10.1111/j.1460-9568.2011.07648.x. View

Double K, Dedov V, Fedorow H, Kettle E, Halliday G, Garner B . The comparative biology of neuromelanin and lipofuscin in the human brain. Cell Mol Life Sci. 2008; 65(11):1669-82. PMC: 11131928. DOI: 10.1007/s00018-008-7581-9. View

Bush W, Garguilo J, Zucca F, Albertini A, Zecca L, Edwards G . The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface. Proc Natl Acad Sci U S A. 2006; 103(40):14785-9. PMC: 1595429. DOI: 10.1073/pnas.0604010103. View

Korytowski W, Sarna T . Bleaching of melanin pigments. Role of copper ions and hydrogen peroxide in autooxidation and photooxidation of synthetic dopa-melanin. J Biol Chem. 1990; 265(21):12410-6. View

Novellino L, Napolitano A, Prota G . 5,6-Dihydroxyindoles in the fenton reaction: a model study of the role of melanin precursors in oxidative stress and hyperpigmentary processes. Chem Res Toxicol. 1999; 12(10):985-92. DOI: 10.1021/tx990020i. View

Double K, Gerlach M, Schunemann V, Trautwein A, Zecca L, Gallorini M . Iron-binding characteristics of neuromelanin of the human substantia nigra. Biochem Pharmacol. 2003; 66(3):489-94. DOI: 10.1016/s0006-2952(03)00293-4. View

Huang D, Ou B, Prior R . The chemistry behind antioxidant capacity assays. J Agric Food Chem. 2005; 53(6):1841-56. DOI: 10.1021/jf030723c. View

Brillas E, Sires I, Oturan M . Electro-Fenton process and related electrochemical technologies based on Fenton's reaction chemistry. Chem Rev. 2009; 109(12):6570-631. DOI: 10.1021/cr900136g. View

10.

Sarna T, Pilas B, Land E, Truscott T . Interaction of radicals from water radiolysis with melanin. Biochim Biophys Acta. 1986; 883(1):162-7. DOI: 10.1016/0304-4165(86)90147-9. View

11.

Winterbourn C . Toxicity of iron and hydrogen peroxide: the Fenton reaction. Toxicol Lett. 1995; 82-83:969-74. DOI: 10.1016/0378-4274(95)03532-x. View

12.

Smith R, Garrett B, Naqvi K, Fulop A, Godfrey S, Marsh J . Mechanistic insights into the bleaching of melanin by alkaline hydrogen peroxide. Free Radic Biol Med. 2017; 108:110-117. DOI: 10.1016/j.freeradbiomed.2017.03.014. View

13.

Pilas B, Sarna T, Kalyanaraman B, Swartz H . The effect of melanin on iron associated decomposition of hydrogen peroxide. Free Radic Biol Med. 1988; 4(5):285-93. DOI: 10.1016/0891-5849(88)90049-4. View

14.

Zecca L, Bellei C, Costi P, Albertini A, Monzani E, Casella L . New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals. Proc Natl Acad Sci U S A. 2008; 105(45):17567-72. PMC: 2582310. DOI: 10.1073/pnas.0808768105. View

15.

Kim E, Kang M, Tschirhart T, Malo M, Dadachova E, Cao G . Spectroelectrochemical Reverse Engineering DemonstratesThat Melanin's Redox and Radical Scavenging Activities Are Linked. Biomacromolecules. 2017; 18(12):4084-4098. DOI: 10.1021/acs.biomac.7b01166. View

16.

Costa T, Younger R, Poe C, Farmer P, Szpoganicz B . Studies on Synthetic and Natural Melanin and Its Affinity for Fe(III) Ion. Bioinorg Chem Appl. 2012; 2012:712840. PMC: 3521465. DOI: 10.1155/2012/712840. View

17.

Chen B, Avshalumov M, Rice M . H(2)O(2) is a novel, endogenous modulator of synaptic dopamine release. J Neurophysiol. 2001; 85(6):2468-76. DOI: 10.1152/jn.2001.85.6.2468. View

18.

Zecca L, Stroppolo A, Gatti A, Tampellini D, Toscani M, Gallorini M . The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. Proc Natl Acad Sci U S A. 2004; 101(26):9843-8. PMC: 470762. DOI: 10.1073/pnas.0403495101. View

19.

Hong L, Liu Y, Simon J . Binding of metal ions to melanin and their effects on the aerobic reactivity. Photochem Photobiol. 2004; 80(3):477-81. DOI: 10.1562/0031-8655(2004)080<0477:BOMITM>2.0.CO;2. View

20.

Panzella L, Gentile G, DErrico G, Della Vecchia N, Errico M, Napolitano A . Atypical structural and π-electron features of a melanin polymer that lead to superior free-radical-scavenging properties. Angew Chem Int Ed Engl. 2013; 52(48):12684-7. DOI: 10.1002/anie.201305747. View