Cognitive Enhancement by Transcranial Photobiomodulation Is Associated With Cerebrovascular Oxygenation of the Prefrontal Cortex

Overview

Journal Front Neurosci

Date 2019 Nov 5

PMID 31680847

Citations 24

Authors

Emma Holmes

Douglas W Barrett

Celeste L Saucedo

Patrick OConnor

Hanli Liu

F Gonzalez-Lima

Affiliations

Soon will be listed here.

Abstract

Transcranial infrared laser stimulation (TILS) is a novel, safe, non-invasive method of brain photobiomodulation. Laser stimulation of the human prefrontal cortex causes cognitive enhancement. To investigate the hemodynamic effects in prefrontal cortex by which this cognitive enhancement occurs, we used functional near-infrared spectroscopy (fNIRS), which is a safe, non-invasive method of monitoring hemodynamics. We measured concentration changes in oxygenated and deoxygenated hemoglobin, total hemoglobin and differential effects in 18 healthy adults during sustained attention and working memory performance, before and after laser of the right prefrontal cortex. We also measured 16 sham controls without photobiomodulation. fNIRS revealed large effects on prefrontal oxygenation during cognitive enhancement post-laser and provided the first demonstration that cognitive enhancement by transcranial photobiomodulation is associated with cerebrovascular oxygenation of the prefrontal cortex. Sham control data served to rule out that the laser effects were due to pre-post task repetition or other non-specific effects. A laser-fNIRS combination may be useful to stimulate and monitor cerebrovascular oxygenation associated with neurocognitive enhancement in healthy individuals and in those with prefrontal hypometabolism, such as in cognitive aging, dementia and many neuropsychiatric disorders.

Citing Articles

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References

Nieder A, Miller E . A parieto-frontal network for visual numerical information in the monkey. Proc Natl Acad Sci U S A. 2004; 101(19):7457-62. PMC: 409940. DOI: 10.1073/pnas.0402239101. View

Vargas E, Barrett D, Saucedo C, Huang L, Abraham J, Tanaka H . Beneficial neurocognitive effects of transcranial laser in older adults. Lasers Med Sci. 2017; 32(5):1153-1162. PMC: 6802936. DOI: 10.1007/s10103-017-2221-y. View

Tian F, Yennu A, Smith-Osborne A, Gonzalez-Lima F, North C, Liu H . Prefrontal responses to digit span memory phases in patients with post-traumatic stress disorder (PTSD): a functional near infrared spectroscopy study. Neuroimage Clin. 2014; 4:808-19. PMC: 4055895. DOI: 10.1016/j.nicl.2014.05.005. View

Jacques S . Optical properties of biological tissues: a review. Phys Med Biol. 2013; 58(11):R37-61. DOI: 10.1088/0031-9155/58/11/R37. View

Wang X, Tian F, Reddy D, Nalawade S, Barrett D, Gonzalez-Lima F . Up-regulation of cerebral cytochrome-c-oxidase and hemodynamics by transcranial infrared laser stimulation: A broadband near-infrared spectroscopy study. J Cereb Blood Flow Metab. 2017; 37(12):3789-3802. PMC: 5718323. DOI: 10.1177/0271678X17691783. View

Wong-Riley M, Liang H, Eells J, Chance B, Henry M, Buchmann E . Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase. J Biol Chem. 2004; 280(6):4761-71. DOI: 10.1074/jbc.M409650200. View

Cotler H, Chow R, Hamblin M, Carroll J . The Use of Low Level Laser Therapy (LLLT) For Musculoskeletal Pain. MOJ Orthop Rheumatol. 2016; 2(5). PMC: 4743666. DOI: 10.15406/mojor.2015.02.00068. View

Eells J, Wong-Riley M, VerHoeve J, Henry M, Buchman E, Kane M . Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy. Mitochondrion. 2005; 4(5-6):559-67. DOI: 10.1016/j.mito.2004.07.033. View

Fox P . The coupling controversy. Neuroimage. 2012; 62(2):594-601. PMC: 4019339. DOI: 10.1016/j.neuroimage.2012.01.103. View

10.

Gonzalez-Lima F, Barrett D . Augmentation of cognitive brain functions with transcranial lasers. Front Syst Neurosci. 2014; 8:36. PMC: 3953713. DOI: 10.3389/fnsys.2014.00036. View

11.

Tian F, Hase S, Gonzalez-Lima F, Liu H . Transcranial laser stimulation improves human cerebral oxygenation. Lasers Surg Med. 2016; 48(4):343-9. PMC: 5066697. DOI: 10.1002/lsm.22471. View

12.

Rojas J, Gonzalez-Lima F . Neurological and psychological applications of transcranial lasers and LEDs. Biochem Pharmacol. 2013; 86(4):447-57. DOI: 10.1016/j.bcp.2013.06.012. View

13.

Drummond S, Bischoff-Grethe A, Dinges D, Ayalon L, Mednick S, Meloy M . The neural basis of the psychomotor vigilance task. Sleep. 2005; 28(9):1059-68. View

14.

Blanco N, Saucedo C, Gonzalez-Lima F . Transcranial infrared laser stimulation improves rule-based, but not information-integration, category learning in humans. Neurobiol Learn Mem. 2017; 139:69-75. DOI: 10.1016/j.nlm.2016.12.016. View

15.

Rojas J, Gonzalez-Lima F . Low-level light therapy of the eye and brain. Eye Brain. 2017; 3:49-67. PMC: 5436183. DOI: 10.2147/EB.S21391. View

16.

Tian F, Delgado M, Dhamne S, Khan B, Alexandrakis G, Romero M . Quantification of functional near infrared spectroscopy to assess cortical reorganization in children with cerebral palsy. Opt Express. 2010; 18(25):25973-86. PMC: 3568529. DOI: 10.1364/OE.18.025973. View

17.

Hopkins J, McLoda T, Seegmiller J, Baxter G . Low-Level Laser Therapy Facilitates Superficial Wound Healing in Humans: A Triple-Blind, Sham-Controlled Study. J Athl Train. 2004; 39(3):223-229. PMC: 522143. View

18.

Holanda V, Chavantes M, Wu X, Anders J . The mechanistic basis for photobiomodulation therapy of neuropathic pain by near infrared laser light. Lasers Surg Med. 2017; 49(5):516-524. DOI: 10.1002/lsm.22628. View

19.

Tedford C, DeLapp S, Jacques S, Anders J . Quantitative analysis of transcranial and intraparenchymal light penetration in human cadaver brain tissue. Lasers Surg Med. 2015; 47(4):312-22. DOI: 10.1002/lsm.22343. View

20.

Blanco N, Maddox W, Gonzalez-Lima F . Improving executive function using transcranial infrared laser stimulation. J Neuropsychol. 2015; 11(1):14-25. PMC: 4662930. DOI: 10.1111/jnp.12074. View