Changes in Choroidal Vascular Parameters Following Pan-retinal Photocoagulation Using Swept-source Optical Coherence Tomography

Overview

Journal Graefes Arch Clin Exp Ophthalmol

Specialty Ophthalmology

Date 2019 Nov 5

PMID 31680197

Citations 8

Authors

Jee Taek Kim

Nari Park

Affiliations

Soon will be listed here.

Abstract

Background: To assess the effect of pan-retinal photocoagulation (PRP) on choroidal vascular parameters in eyes with advanced diabetic retinopathy (DR).

Methods: Forty patients (65 eyes) with severe nonproliferative DR or proliferative DR who underwent PRP were included. Changes in choroidal vascular parameters were assessed at 3, 6, and 12 months after PRP by using swept-source optical coherence tomography (OCT) and OCT angiography and were compared with baseline values.

Results: Choroidal vascularity index (CVI) significantly decreased from 66.27% ± 1.55% at baseline to 65.85% ± 1.61%, 65.77% ± 1.29%, and 65.74% ± 1.60% at 3, 6, and 12 months after PRP, respectively. The ratio of luminal area to stromal area (L/S ratio) also significantly decreased from 1.98 ± 0.15 at baseline to 1.94 ± 0.14, 1.95 ± 0.13, and 1.93 ± 0.14 at 3, 6, and 12 months after PRP, respectively. The subfoveal choroidal thickness (SFCT) similarly showed a significant decrease from 319.50 ± 56.64 μm at baseline to 299. 07 ± 51.14 μm, 294.70 ± 58.96 μm, and 280.93 ± 53.57 μm at 3, 6, and 12 months after PRP, respectively. However, the choriocapillaris vessel density in both the fovea and parafovea showed no significant differences following PRP.

Conclusion: Eyes with advanced DR showed a significant reduction in CVI, L/S ratio, and SFCT over 12 months after PRP treatment.

Citing Articles

Long-Term Effects of Intravitreal Ranibizumab Compared With Panretinal Photocoagulation on Optical Coherence Tomography Measured Choroidal Thickness and Vascularity.

Lee B, Josic K, Nittala M, Velaga S, Karamat A, Srinivas S Transl Vis Sci Technol. 2024; 13(7):19.

PMID: 39058503 PMC: 11282891. DOI: 10.1167/tvst.13.7.19.

Qualitative and quantitative evaluation of diabetic choroidopathy using ultra-widefield indocyanine green angiography.

Choi S, Kim Y, Lee J, Lee J, Yoon Y Sci Rep. 2023; 13(1):2577.

PMID: 36781980 PMC: 9925819. DOI: 10.1038/s41598-023-29216-5.

Aqueous Humor Analyses in Patients with Diabetic Retinopathy Who Had Undergone Panretinal Photocoagulation.

Kwon J, Oh J J Diabetes Res. 2022; 2022:1897344.

PMID: 35770197 PMC: 9236844. DOI: 10.1155/2022/1897344.

Choroidal imaging using optical coherence tomography: techniques and interpretations.

Sekiryu T Jpn J Ophthalmol. 2022; 66(3):213-226.

PMID: 35171356 DOI: 10.1007/s10384-022-00902-7.

Correlations between choroidal thickness and renal function in patients with retinal vein occlusion.

Choi S, Oh J, Kim J Sci Rep. 2020; 10(1):16865.

PMID: 33033387 PMC: 7545166. DOI: 10.1038/s41598-020-74058-0.

References

Cao J, McLeod S, Merges C, Lutty G . Choriocapillaris degeneration and related pathologic changes in human diabetic eyes. Arch Ophthalmol. 1998; 116(5):589-97. DOI: 10.1001/archopht.116.5.589. View

Song Y, Tani T, Omae T, Ishibazawa A, Yoshioka T, Takahashi K . Retinal blood flow reduction after panretinal photocoagulation in Type 2 diabetes mellitus: Doppler optical coherence tomography flowmeter pilot study. PLoS One. 2018; 13(11):e0207288. PMC: 6224130. DOI: 10.1371/journal.pone.0207288. View

Kim M, Ha M, Choi S, Park Y . Choroidal vascularity index in type-2 diabetes analyzed by swept-source optical coherence tomography. Sci Rep. 2018; 8(1):70. PMC: 5758605. DOI: 10.1038/s41598-017-18511-7. View

Sonoda S, Sakamoto T, Yamashita T, Shirasawa M, Uchino E, Terasaki H . Choroidal structure in normal eyes and after photodynamic therapy determined by binarization of optical coherence tomographic images. Invest Ophthalmol Vis Sci. 2014; 55(6):3893-9. DOI: 10.1167/iovs.14-14447. View

Tan K, Gupta P, Agarwal A, Chhablani J, Cheng C, Keane P . State of science: Choroidal thickness and systemic health. Surv Ophthalmol. 2016; 61(5):566-81. DOI: 10.1016/j.survophthal.2016.02.007. View

Sayanagi K, Ikuno Y, Uematsu S, Nishida K . Features of the choriocapillaris in myopic maculopathy identified by optical coherence tomography angiography. Br J Ophthalmol. 2017; 101(11):1524-1529. DOI: 10.1136/bjophthalmol-2016-309628. View

Agrawal R, Wei X, Goud A, Vupparaboina K, Jana S, Chhablani J . Influence of scanning area on choroidal vascularity index measurement using optical coherence tomography. Acta Ophthalmol. 2017; 95(8):e770-e775. DOI: 10.1111/aos.13442. View

Grunwald J, Brucker A, Petrig B, Riva C . Retinal blood flow regulation and the clinical response to panretinal photocoagulation in proliferative diabetic retinopathy. Ophthalmology. 1989; 96(10):1518-22. DOI: 10.1016/s0161-6420(89)32697-2. View

Hidayat A, FINE B . Diabetic choroidopathy. Light and electron microscopic observations of seven cases. Ophthalmology. 1985; 92(4):512-22. View

10.

Okamoto M, Matsuura T, Ogata N . EFFECTS OF PANRETINAL PHOTOCOAGULATION ON CHOROIDAL THICKNESS AND CHOROIDAL BLOOD FLOW IN PATIENTS WITH SEVERE NONPROLIFERATIVE DIABETIC RETINOPATHY. Retina. 2015; 36(4):805-11. DOI: 10.1097/IAE.0000000000000800. View

11.

Agrawal R, Chhablani J, Tan K, Shah S, Sarvaiya C, Banker A . CHOROIDAL VASCULARITY INDEX IN CENTRAL SEROUS CHORIORETINOPATHY. Retina. 2016; 36(9):1646-51. DOI: 10.1097/IAE.0000000000001040. View

12.

Lutty G . Diabetic choroidopathy. Vision Res. 2017; 139:161-167. PMC: 5858724. DOI: 10.1016/j.visres.2017.04.011. View

13.

Zheng Y, He M, Congdon N . The worldwide epidemic of diabetic retinopathy. Indian J Ophthalmol. 2012; 60(5):428-31. PMC: 3491270. DOI: 10.4103/0301-4738.100542. View

14.

. Grading diabetic retinopathy from stereoscopic color fundus photographs--an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1991; 98(5 Suppl):786-806. View

15.

Tan K, Laude A, Yip V, Loo E, Wong E, Agrawal R . Choroidal vascularity index - a novel optical coherence tomography parameter for disease monitoring in diabetes mellitus?. Acta Ophthalmol. 2016; 94(7):e612-e616. DOI: 10.1111/aos.13044. View

16.

Kim J, Lee D, Joe S, Kim J, Yoon Y . Changes in choroidal thickness in relation to the severity of retinopathy and macular edema in type 2 diabetic patients. Invest Ophthalmol Vis Sci. 2013; 54(5):3378-84. DOI: 10.1167/iovs.12-11503. View

17.

Lee C, Smith J, Kang-Mieler J, Budzynski E, Linsenmeier R . Decreased circulation in the feline choriocapillaris underlying retinal photocoagulation lesions. Invest Ophthalmol Vis Sci. 2011; 52(6):3398-403. PMC: 3109035. DOI: 10.1167/iovs.10-6560. View

18.

Nickla D, Wallman J . The multifunctional choroid. Prog Retin Eye Res. 2010; 29(2):144-68. PMC: 2913695. DOI: 10.1016/j.preteyeres.2009.12.002. View

19.

Ahn J, Yoo G, Kim J, Kim S, Oh J . Choriocapillaris layer imaging with swept-source optical coherence tomography angiography in lamellar and full-thickness macular hole. Graefes Arch Clin Exp Ophthalmol. 2017; 256(1):11-21. DOI: 10.1007/s00417-017-3814-7. View

20.

Zhang Z, Meng X, Wu Z, Zou W, Zhang J, Zhu D . Changes in Choroidal Thickness After Panretinal Photocoagulation for Diabetic Retinopathy: A 12-Week Longitudinal Study. Invest Ophthalmol Vis Sci. 2015; 56(4):2631-8. DOI: 10.1167/iovs.14-16226. View