Impact of Delivery Mode-associated Gut Microbiota Dynamics on Health in the First Year of Life

Overview

Journal Nat Commun

Specialty Biology

Date 2019 Nov 3

PMID 31676793

Citations 182

Authors

Marta Reyman

Marlies A van Houten

Debbie van Baarle

Astrid A T M Bosch

Wing Ho Man

Mei Ling J N Chu

Kayleigh Arp

Rebecca L Watson

Elisabeth A M Sanders

Susana Fuentes

Debby Bogaert

Affiliations

Soon will be listed here.

Abstract

The early-life microbiome appears to be affected by mode of delivery, but this effect may depend on intrapartum antibiotic exposure. Here, we assess the effect of delivery mode on gut microbiota, independent of intrapartum antibiotics, by postponing routine antibiotic administration to mothers until after cord clamping in 74 vaginally delivered and 46 caesarean section born infants. The microbiota differs between caesarean section born and vaginally delivered infants over the first year of life, showing enrichment of Bifidobacterium spp., and reduction of Enterococcus and Klebsiella spp. in vaginally delivered infants. The microbiota composition at one week of life is associated with the number of respiratory infections over the first year. The taxa driving this association are more abundant in caesarean section born children, providing a possible link between mode of delivery and susceptibility to infectious outcomes.

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