» Articles » PMID: 31667065

Myriad Facades of Keratocanthoma: Benignity VS Malignancy

Overview
Publisher Elsevier
Date 2019 Nov 1
PMID 31667065
Citations 1
Authors
Affiliations
Soon will be listed here.
Abstract

Keratoacanthoma (KA) is a self-limiting benign epithelial neoplasm. It occurs predominantly on sun-exposed areas of the body and is believed to arise from hair follicle. It shows a unique behavior in being clinically benign and microscopically malignant. Earlier it was considered as a pseudomalignant lesion but now it is believed to be pseudobenign in nature. The most common concern is related to its nosological position at the border of malignancy and benignity. We hereby report a rare case of keratoacanthomatous type of squamous cell carcinoma in an elderly female showing aggressive nature of the lesion. The various terminologies used for KA in the past have also been tabulated.

Citing Articles

Keratoacanthoma versus Squamous-Cell Carcinoma: Histopathological Features and Molecular Markers.

Bahmad H, Stoyanov K, Mendez T, Trinh S, Terp K, Qian L Dermatopathology (Basel). 2024; 11(4):272-285.

PMID: 39449378 PMC: 11503433. DOI: 10.3390/dermatopathology11040029.

References
1.
Kamath P, Pereira T, Chande M, Shetty S . Keratoacanthoma of the lip: A case report with emphasis on histogenesis. J Oral Maxillofac Pathol. 2017; 21(1):115-118. PMC: 5406790. DOI: 10.4103/jomfp.JOMFP_217_16. View

2.
Savage J, Maize Sr J . Keratoacanthoma clinical behavior: a systematic review. Am J Dermatopathol. 2013; 36(5):422-9. DOI: 10.1097/DAD.0000000000000031. View

3.
Ra S, Su A, Li X, Zhou J, Cochran A, Kulkarni R . Keratoacanthoma and squamous cell carcinoma are distinct from a molecular perspective. Mod Pathol. 2015; 28(6):799-806. DOI: 10.1038/modpathol.2015.5. View

4.
Kern W, McCray M . The histopathologic differentiation of keratoacanthoma and squamous cell carcinoma of the skin. J Cutan Pathol. 1980; 7(5):318-25. DOI: 10.1111/j.1600-0560.1980.tb01202.x. View

5.
Cribier B, Asch P, Grosshans E . Differentiating squamous cell carcinoma from keratoacanthoma using histopathological criteria. Is it possible? A study of 296 cases. Dermatology. 1999; 199(3):208-12. DOI: 10.1159/000018276. View