Validation of Diffuse Correlation Spectroscopy Against O-water PET for Regional Cerebral Blood Flow Measurement in Neonatal Piglets

Overview

Journal J Cereb Blood Flow Metab

Publisher Sage Publications

Specialties Cardiology & Vascular Diseases
Endocrinology
Neurology

Date 2019 Nov 1

PMID 31665953

Citations 32

Authors

Martina Giovannella

Bjorn Andresen

Julie B Andersen

Sahla El-Mahdaoui

Davide Contini

Lorenzo Spinelli

Alessandro Torricelli

Gorm Greisen

Turgut Durduran

Udo M Weigel

Ian Law

Affiliations

Soon will be listed here.

Abstract

Diffuse correlation spectroscopy (DCS) can non-invasively and continuously asses regional cerebral blood flow (rCBF) at the cot-side by measuring a blood flow index (BFI) in non-traditional units of cm/s. We have validated DCS against positron emission tomography using O-labeled water (O-water PET) in a piglet model allowing us to derive a conversion formula for BFI to rCBF in conventional units (ml/100g/min). Neonatal piglets were continuously monitored by the BabyLux device integrating DCS and time resolved near infrared spectroscopy (TRS) while acquiring O-water PET scans at baseline, after injection of acetazolamide and during induced hypoxic episodes. BFI by DCS was highly correlated with rCBF (R = 0.94, < 0.001) by PET. A scaling factor of 0.89 (limits of agreement for individual measurement: 0.56, 1.39)×10× (ml/100g/min)/(cm/s) was used to derive baseline rCBF from baseline BFI measurements of another group of piglets and of healthy newborn infants showing an agreement with expected values. These results pave the way towards non-invasive, cot-side absolute CBF measurements by DCS on neonates.

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