Maternal Interleukin-6 Is Associated With Macaque Offspring Amygdala Development and Behavior

Overview

Journal Cereb Cortex

Publisher Oxford University Press

Specialty Neurology

Date 2019 Oct 31

PMID 31665252

Citations 15

Authors

Julian S B Ramirez

Alice M Graham

Jacqueline R Thompson

Jennifer Y Zhu

Darrick Sturgeon

Jennifer L Bagley

Elina Thomas

Samantha Papadakis

Muhammed Bah

Anders Perrone

Eric Earl

Oscar Miranda-Dominguez

Eric Feczko

Eric J Fombonne

David G Amaral

Joel T Nigg

Elinor L Sullivan

Damien A Fair

Affiliations

Soon will be listed here.

Abstract

Human and animal cross-sectional studies have shown that maternal levels of the inflammatory cytokine interleukin-6 (IL-6) may compromise brain phenotypes assessed at single time points. However, how maternal IL-6 associates with the trajectory of brain development remains unclear. We investigated whether maternal IL-6 levels during pregnancy relate to offspring amygdala volume development and anxiety-like behavior in Japanese macaques. Magnetic resonance imaging (MRI) was administered to 39 Japanese macaque offspring (Female: 18), providing at least one or more time points at 4, 11, 21, and 36 months of age with a behavioral assessment at 11 months of age. Increased maternal third trimester plasma IL-6 levels were associated with offspring's smaller left amygdala volume at 4 months, but with more rapid amygdala growth from 4 to 36 months. Maternal IL-6 predicted offspring anxiety-like behavior at 11 months, which was mediated by reduced amygdala volumes in the model's intercept (i.e., 4 months). The results increase our understanding of the role of maternal inflammation in the development of neurobehavioral disorders by detailing the associations of a commonly examined inflammatory indicator, IL-6, on amygdala volume growth over time, and anxiety-like behavior.

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