Highly Sensitive Microstructure-Based Flexible Pressure Sensor for Quantitative Evaluation of Motor Function Recovery After Spinal Cord Injury

Overview

Journal Sensors (Basel)

Publisher MDPI

Specialty Biotechnology

Date 2019 Oct 31

PMID 31661821

Citations 3

Authors

Dan Yang

Wei Yang

Lianhui Li

Kai Zhou

Mingming Hao

Xingyu Feng

Ting Zhang

Yaobo Liu

Affiliations

Soon will be listed here.

Abstract

Behavioral assessment, such as systematic scoring or biomechanical measurement, is often used to evaluate the extent of the damage and the degree of recovery after spinal cord injury. However, the use of these methods in standardized evaluation is limited because they are subjective and require complex test systems to implement. Here, we report a novel, flexible, microstructure-based pressure sensor and demonstrate its superior sensitivity (235.12 kPa for 5.5~135 Pa and 2.24 kPa for 0.6~25 kPa), good waterproofness, fast response and recovery times (response time: 8 ms, recovery time: 12 ms), stable response over 8000 loading/unloading cycles, and wide sensing range. These features readily allow the sensor to be comfortably attached to the hindlimbs of mice for full-range, real-time detection of their behavior, such as crawling and swimming, helping to realize quantitative evaluation of animal motor function recovery after spinal cord injury.

Citing Articles

Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives.

Gao Y, Wang Y, Wu Y, Liu S Front Cell Neurosci. 2024; 18:1362494.

PMID: 38784712 PMC: 11111957. DOI: 10.3389/fncel.2024.1362494.

Dual electrical stimulation at spinal-muscular interface reconstructs spinal sensorimotor circuits after spinal cord injury.

Zhou K, Wei W, Yang D, Zhang H, Yang W, Zhang Y Nat Commun. 2024; 15(1):619.

PMID: 38242904 PMC: 10799086. DOI: 10.1038/s41467-024-44898-9.

A Flexible Pressure Sensor with Ink Printed Porous Graphene for Continuous Cardiovascular Status Monitoring.

Peng Y, Zhou J, Song X, Pang K, Samy A, Hao Z Sensors (Basel). 2021; 21(2).

PMID: 33445532 PMC: 7828094. DOI: 10.3390/s21020485.

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