The Eye Sees Eye to Eye With the Immune System: The 2019 Proctor Lecture

Overview

Journal Invest Ophthalmol Vis Sci

Specialty Ophthalmology

Date 2019 Oct 30

PMID 31661549

Citations 10

Authors

Jerry Y Niederkorn

Affiliations

Soon will be listed here.

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References

Beauregard C, Stevens C, Mayhew E, Niederkorn J . Cutting edge: atopy promotes Th2 responses to alloantigens and increases the incidence and tempo of corneal allograft rejection. J Immunol. 2005; 174(11):6577-81. DOI: 10.4049/jimmunol.174.11.6577. View

Niederkorn J, Mellon J . Anterior chamber-associated immune deviation promotes corneal allograft survival. Invest Ophthalmol Vis Sci. 1996; 37(13):2700-7. View

Egan R, Yorkey C, Black R, Loh W, Stevens J, Woodward J . Peptide-specific T cell clonal expansion in vivo following immunization in the eye, an immune-privileged site. J Immunol. 1996; 157(6):2262-71. View

Abi-Hanna D, Wakefield D, Watkins S . HLA antigens in ocular tissues. I. In vivo expression in human eyes. Transplantation. 1988; 45(3):610-3. DOI: 10.1097/00007890-198803000-00021. View

Medawar P . Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. Br J Exp Pathol. 1948; 29(1):58-69. PMC: 2073079. View

Hori J, Wang M, Miyashita M, Tanemoto K, Takahashi H, Takemori T . B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts. J Immunol. 2006; 177(9):5928-35. DOI: 10.4049/jimmunol.177.9.5928. View

Ferguson T, Hayashi J, Kaplan H . Regulation of the systemic immune response by visible light and the eye. FASEB J. 1988; 2(14):3017-21. DOI: 10.1096/fasebj.2.14.2972579. View

Neelam S, Mellon J, Wilkerson A, Niederkorn J . Induction of Contrasuppressor Cells and Loss of Immune Privilege Produced by Corneal Nerve Ablation. Invest Ophthalmol Vis Sci. 2018; 59(11):4738-4747. PMC: 6161365. DOI: 10.1167/iovs.18-24894. View

Reyes N, OKoren E, Saban D . New insights into mononuclear phagocyte biology from the visual system. Nat Rev Immunol. 2017; 17(5):322-332. PMC: 5810371. DOI: 10.1038/nri.2017.13. View

10.

Wang S, Boonman Z, Li H, He Y, Jager M, Toes R . Role of TRAIL and IFN-gamma in CD4+ T cell-dependent tumor rejection in the anterior chamber of the eye. J Immunol. 2003; 171(6):2789-96. DOI: 10.4049/jimmunol.171.6.2789. View

11.

Knisely T, Luckenbach M, Fischer B, Niederkorn J . Destructive and nondestructive patterns of immune rejection of syngeneic intraocular tumors. J Immunol. 1987; 138(12):4515-23. View

12.

Di Zazzo A, Kheirkhah A, Abud T, Goyal S, Dana R . Management of high-risk corneal transplantation. Surv Ophthalmol. 2016; 62(6):816-827. PMC: 5479764. DOI: 10.1016/j.survophthal.2016.12.010. View

13.

von Schantz M, Provencio I, Foster R . Recent developments in circadian photoreception: more than meets the eye. Invest Ophthalmol Vis Sci. 2000; 41(7):1605-7. View

14.

. The collaborative corneal transplantation studies (CCTS). Effectiveness of histocompatibility matching in high-risk corneal transplantation. The Collaborative Corneal Transplantation Studies Research Group. Arch Ophthalmol. 1992; 110(10):1392-403. View

15.

Schaumburg C, Siemasko K, de Paiva C, Wheeler L, Niederkorn J, Pflugfelder S . Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. J Immunol. 2011; 187(7):3653-62. DOI: 10.4049/jimmunol.1101442. View

16.

Griffith T, Brunner T, Fletcher S, Green D, Ferguson T . Fas ligand-induced apoptosis as a mechanism of immune privilege. Science. 1995; 270(5239):1189-92. DOI: 10.1126/science.270.5239.1189. View

17.

Reyes N, Chen P, Niederkorn J . Allergic conjunctivitis renders CD4(+) T cells resistant to t regulatory cells and exacerbates corneal allograft rejection. Am J Transplant. 2013; 13(5):1181-92. PMC: 3640580. DOI: 10.1111/ajt.12198. View

18.

Niederkorn J, Chen P, Mellon J, Stevens C, Mayhew E . Allergic airway hyperreactivity increases the risk for corneal allograft rejection. Am J Transplant. 2009; 9(5):1017-26. PMC: 2737278. DOI: 10.1111/j.1600-6143.2009.02603.x. View

19.

Hazlett L, McClellan S, Barrett R, Liu J, Zhang Y, Lighvani S . Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection. Invest Ophthalmol Vis Sci. 2007; 48(2):797-807. DOI: 10.1167/iovs.06-0882. View

20.

Ferguson T, Mahendra S, Hooper P, Kaplan H . The wavelength of light governing intraocular immune reactions. Invest Ophthalmol Vis Sci. 1992; 33(5):1788-95. View