The Emerging Role of Sperm-Associated Antigen 6 Gene in the Microtubule Function of Cells and Cancer

Overview

Journal Mol Ther Oncolytics

Publisher Cell Press

Date 2019 Oct 30

PMID 31660426

Citations 11

Authors

Da-Fang Zheng

Qi Wang

Jing-Ping Wang

Zheng-Qi Bao

Shi-Wu Wu

Li Ma

Da-Min Chai

Z Peter Wang

Yi-Sheng Tao

Affiliations

Soon will be listed here.

Abstract

Accumulated evidence shows that sperm-associated antigen 6 (SPAG6) gene has multiple biological functions. It maintains the normal function of a variety of cells including ciliary/flagellar biogenesis and polarization, neurogenesis, and neuronal migration. Moreover, SPAG6 is found to be critically involved in auditory transduction and the fibroblast life cycle. Furthermore, SPAG6 plays an essential role in immuno-regulation. Notably, SPAG6 has been demonstrated to participate in the occurrence and progression of a variety of human cancers. New evidence shows that SPAG6 gene regulates tumor cell proliferation, apoptosis, invasion, and metastasis. Therefore, in this review, we describe the physiological function and mechanism of SPAG6 in human normal cells and cancer cells. We also highlight that SPAG6 gene may be an effective biomarker for the diagnosis of human cancer. Taken together, targeting SPAG6 could be a novel strategy for the treatment of human diseases including cancer.

Citing Articles

SPAG6 overexpression decreases the pro-apoptotic effect of daunorubicin in acute myeloid leukemia cells through the ROS/JNK MAPK axis in a GSTP1-dependent manner.

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A comprehensive pan-cancer analysis revealing as a novel diagnostic, prognostic and immunological biomarker in tumor.

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Upregulated SPAG6 correlates with increased STAT1 and is associated with reduced sensitivity of interferon-α response in BCR::ABL1 negative myeloproliferative neoplasms.

Ding L, Luo J, Du J, Zhao B, Luo J, Pan S Cancer Sci. 2023; 114(11):4445-4458.

PMID: 37681349 PMC: 10637088. DOI: 10.1111/cas.15950.

Clinical detection, diagnosis and treatment of morphological abnormalities of sperm flagella: A review of literature.

Wang J, Wang W, Shen L, Zheng A, Meng Q, Li H Front Genet. 2022; 13:1034951.

PMID: 36425067 PMC: 9679630. DOI: 10.3389/fgene.2022.1034951.

DNMT3b-mediated SPAG6 promoter hypermethylation affects lung squamous cell carcinoma development through the JAK/STAT pathway.

Wu Q, Yan Y, Shi S, Qi Q, Han J Am J Transl Res. 2022; 14(10):6964-6977.

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