An Old Friend: Uric Acid and Its Association with Fractional Flow Reserve

Overview

Journal Turk J Med Sci

Specialty General Medicine

Date 2019 Oct 28

PMID 31655503

Citations 2

Authors

Salih Topal

Burak Sezenoz

Mustafa Candemir

Eser Acikgoz

Sadik Kadri Acikgoz

Nuri Bulent Boyaci

Affiliations

Soon will be listed here.

Abstract

Background/aim: The aim of this study was to investigate the importance of preprocedural uric acid (UA) level in predicting fractional flow reserve (FFR) results of intermediate coronary lesions in patients with stable coronary artery disease undergoing coronary angiography.

Materials And Methods: We retrospectively analyzed 293 patients who underwent FFR measurement to determine the significance of intermediate coronary stenosis detected by conventional coronary angiography. Patients were divided into 2 groups: Group 1 (n = 127) included patients with FFR of <0.80 (hemodynamically significant lesions), and Group 2 (n = 169) consisted of patients with FFR of >0.80 (hemodynamically nonsignificant lesions). Uric acid levels were assessed in both groups with the enzymatic colorimetric method by clinical chemistry autoanalyzer.

Results: The mean UA level was significantly higher in patients whose FFR indicated hemodynamically significant coronary lesions (UA: 5.43 ± 1.29 mg/dL in Group 1 vs. 4.51 ± 1.34 mg/dL in Group 2, P < 0.001).

Conclusion: Elevated UA levels are associated with hemodynamically significant coronary lesions measured with FFR. Uric acid may be used as a predictor of hemodynamically compromised coronary lesions before FFR procedures.

Citing Articles

The uric acid/HDL-C ratio may predict significant coronary stenosis in moderate left main coronary artery lesions: an intravascular ultrasonography study.

Demir O, Arslan A, Kinik M, Sensoy B, Demir G Lipids Health Dis. 2024; 23(1):233.

PMID: 39080618 PMC: 11289968. DOI: 10.1186/s12944-024-02193-y.

Uric Acid to High-Density Lipoprotein Cholesterol Ratio is a Novel Marker to Predict Functionally Significant Coronary Artery Stenosis.

Li F, Zhao D, Li Q, Lin X, Sun H, Fan Q J Interv Cardiol. 2022; 2022:9057832.

PMID: 36311279 PMC: 9584719. DOI: 10.1155/2022/9057832.

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